1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.
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http://dx.doi.org/10.1111/j.1440-1681.2006.04460.x | DOI Listing |
Mol Genet Genomics
January 2025
Department of Molecular Phytopathology and Biotechnology, Institute of Phytopathology, Christian-Albrechts-University of Kiel, 24118, Kiel, Germany.
Brassica villosa is characterized by its dense hairiness and high resistance against the fungal pathogen Sclerotinia sclerotiorum. Information on the genetic and molecular mechanisms governing trichome development in B. villosa is rare.
View Article and Find Full Text PDFBiochemistry
January 2025
Sunita Sanghi Centre of Aging and Neurodegenerative Diseases (SCAN), Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Aggregation of α-synuclein (α-Syn) and Lewy body (LB) formation are the key pathological events implicated in Parkinson's disease (PD) that spread in a prion-like manner. However, biophysical and structural characteristics of toxic α-Syn species and molecular events that drive early events in the propagation of α-Syn amyloids in a prion-like manner remain elusive. We used a neuronal cell model to demonstrate the size-dependent native biological activities of α-Syn fibril seeds.
View Article and Find Full Text PDFSci Rep
January 2025
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02134, USA.
Many aquatic organisms utilize suction-based organs to adhere to diverse substrates in unpredictable environments. For multiple fish species, these adhesive discs include a softer disc margin consisting of surface structures called papillae, which stabilize and seal on variable substrates. The size, arrangement, and density of these papillae are quite diverse among different species, generating complex disc patterns produced by these structures.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Plant Biology, Faculty of Science, University of Yaounde I, P.O. Box: 812, Yaounde, Cameroon.
Understanding Atlantic tropical forests' ecological dynamics and carbon storage potential in Cameroon is crucial for guiding sustainable management and conservation strategies. These forests play a significant role in carbon sequestration and biodiversity conservation. This study aimed to fill existing knowledge gaps by characterising plant communities, assessing the vegetation structure, and quantifying the potential of carbon stocks.
View Article and Find Full Text PDFFront Plant Sci
December 2024
Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, China.
, native to North America, is an invasive species in many areas of the world, where it causes serious damage to natural ecosystems and economic losses. However, a dearth of genetic resources and molecular markers has hampered our understanding of its invasion history. Here, we assembled 40 complete chloroplast genomes of species, including 21 individuals, 15 individuals, and four individuals, the sizes of which ranged from 152,412 bp to 153,170 bp.
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