Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertension.

Clin Exp Pharmacol Physiol

The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

Published: September 2006

1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.

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http://dx.doi.org/10.1111/j.1440-1681.2006.04460.xDOI Listing

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