AI Article Synopsis
- Membrane transport proteins from the ATP-binding cassette (ABC) family help organisms defend against toxic substances, including anticancer drugs, which can lead to cellular resistance and decreased drug effectiveness.
- Inhibitors targeting these transport proteins could potentially reverse this resistance, improving treatment outcomes for patients facing drug-resistant cancers.
- The review discusses various inhibitors of multidrug resistance-related ABC proteins and emphasizes how the metabolism of these inhibitors, especially natural compounds, significantly affects their ability to combat drug resistance.
Article Abstract
Membrane transport proteins belonging to the ATP-binding cassette (ABC) family of transport proteins play a central role in the defence of organisms against toxic compounds, including anticancer drugs. However, for compounds that are designed to display a toxic effect, this defence system diminishes their effectiveness. This is typically the case in the development of cellular resistance to anticancer drugs. Inhibitors of these transporters are thus potentially useful tools to reverse this transporter-mediated cellular resistance to anticancer drugs and, eventually, to enhance the effectiveness of the treatment of patients with drug-resistant cancer. This review highlights the various types of inhibitors of several multidrug resistance-related ABC proteins, and demonstrates that the metabolism of inhibitors, as illustrated by recent data obtained for various natural compound inhibitors, may have considerable implications for their effect on drug transport and their potential for treatment of drug resistance.
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| http://dx.doi.org/10.1517/17425255.1.2.219 | DOI Listing |
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