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[Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and of pulmonary emphysema].
Recenti Prog Med
January 2012
Dipartimento di Medicina, Universita di Ferrara, Italy.
There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we believe that more human translational studies are necessaries, otherwise the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this disease.
View Article and Find Full Text PDFEnfisema polmonare progressivo successivo ad inalazione di arachide senza rilievo di persistenza del corpo estraneo. Progressive pulmonary emphysema after inhalation of peanuts without persistence of the foreign body.
Pediatr Med Chir
October 2006
Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste.
[Longitudinal follow-up evaluation of pulmonary emphysema using high-resolution Computed Tomography (HRCT) study and pulmonary function tests].
Radiol Med
September 2001
Radiologia Pneumonefro, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Purpose: To evaluate the usefulness of HRCT in the identification of longitudinal progression of emphysema and to establish the sensitivity of HRCT compared with functional tests.
Material And Methods: 15 ex-smokers with chronic obstructive lung disease were studied, using two consecutive HRCT examinations (t1 and t2); emphysema was evaluated by HRCT visual score and, at the same time, pulmonary function tests.
Results: As a whole, the extension of emphysema with HRCT presented a good correlation with Tiffeneau index (IT).
[Automatic evaluation of total lung capacity and of emphysema involvement with spiral computerized tomography (CT) in obstructive pneumonia].
Radiol Med
July 2001
Policlinico S. Orsola Malpighi, Via Massarenti 9, 40138 Bologna.
Objective: To evaluate, in patients with chronic obstructive lung disease or chronic bronchitis, inspiratory helical CT with 3D postprocessing, to measure lung volumes and the amount of emphysema and to compare these measurements with lung function tests.
Material And Methods: Seventeen patients with chronic obstructive lung disease disease or chronic bronchitis underwent pulmonary function tests and helical CT after a full inspiration with 3D postprocessing (lower threshold -1024 HU, upper thresholds -200, -300 and -400 HU). Lung inspiratory volumes (TLC-CT) were determined for each model; the amount of emphysema was evaluated by means of an automatic score and a visual score with HRCT.
[The surgical physiopathology of essential pulmonary emphysema and volume-reduction intervention].
Minerva Chir
November 1998
Dipartimento di Chirurgia, IRCCS San Matteo, Pavia.
The breaking of the interalveolar septa represents, in the pathogenetic mechanism of emphysema, a final event, common to the different etiologic agents. This elementary injury causes a series of consequences, essentially of mechanic-structural type (intrapulmonary aerial spaces-confining parenchyma collapse, bronchial obstruction, dead space augmentation) on the thin and articulate bronchoalveolar architecture, whose final rearrangement determines, at least in part, the clinical picture. In short, the break of alveolar septa involves the formation of intraparenchymal aerial spaces with collapse of the confining lung; the compensatory mechanism to this situation, involves the hyperexpansion of the thoracic cage and flattening of the diaphragm, with the aim of allowing ventilation of the healthy residual parenchyma.
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