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Biophysical characterization and in silico analysis of natural and synthetic compounds targeting Listeria monocytogenes HtrA protease.
Mol Divers
November 2024
Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, 600 025, India.
HtrA protein is a member of a serine protease family with dual functions as a protease and molecular chaperone. It is a virulence factor in many bacteria, including the food-borne pathogen Listeria monocytogenes (Lm), which induces listeriosis in humans. Hence, inhibitors of LmHtrA protease have great importance in the control of infection.
View Article and Find Full Text PDFA Quick Sequential Organ Failure Assessment (qSOFA) Score Greater than 1 and Shortened Ampicillin Use Predict Death and One-Year Mortality in Hospitalized Patients with Non-Perinatal Invasive Listeriosis: A Retrospective Analysis of 118 Consecutive Cases.
Microorganisms
November 2024
Department of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Branch, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
causes listeriosis, a serious foodborne illness with a high mortality rate, especially in vulnerable populations. It accounts for 19% of foodborne deaths, with invasive cases having a mortality rate of up to 44%, leading to conditions like meningitis, bacteremia, and meningoencephalitis. However, the prognostic factors remain unclear.
View Article and Find Full Text PDFin Fruits and Vegetables: Antimicrobial Resistance, Biofilm, and Genomic Insights.
Antibiotics (Basel)
November 2024
Centro de Investigación en Biotecnología Microbiana y Alimentaria, Departamento de Ciencias Básicas, División de Desarrollo Biotecnológico, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, Col. Lindavista, Ocotlán 47820, Jalisco, Mexico.
Background/objectives: is a foodborne pathogen that can infect both humans and animals and cause noninvasive gastrointestinal listeriosis or invasive listeriosis. The objectives of this study were to determine the genetic diversity of ; the genes associated with its resistance to antibiotics, benzalkonium chloride (BC), and cadmium chloride (CdCl); and its biofilm formation.
Methods: A total of 132 fresh fruits (44 samples) and vegetables (88 samples) were selected for this study.
In 2022, the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), U.
View Article and Find Full Text PDFWhole genome sequencing reveals circulation of potentially virulent Listeria innocua strains with novel genomic features in cattle farm environments in Dhaka, Bangladesh.
Infect Genet Evol
December 2024
Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address:
Article Synopsis
- * Both isolates shared nearly identical genomic features and contained 13 virulence genes related to invasion, adhesion, and stress response, as well as genes for resistance to fosfomycin and copper.
- * Notably, the research identified a composite transposon unique to Listeria species, four prophage regions, and performed Multilocus Sequence Typing (MLST) which indicated a close relationship between the isolates, revealing their potential for transmission.
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