AI Article Synopsis
- The study focuses on the development of new compounds called N-sulfonyl-2-indole carboxamides that interact with PPAR-gamma, a receptor important for various biological functions.
- Through chemical optimization, a specific compound named 4q was found to have a strong binding affinity to PPAR-gamma, with an IC(50) value of 50 nM, indicating its potential effectiveness.
- Initial tests in cells suggest that these compounds could be useful in treating osteoporosis, a condition characterized by weak and brittle bones.
Article Abstract
The synthesis and structure-activity relationships of a novel series of N-sulfonyl-2-indole carboxamides that bind to peroxisome proliferator-activated receptor gamma (PPAR-gamma) are reported. Chemical optimization of the series led to the identification of 4q (IC(50)=50 nM) as a potent binding agent of PPAR-gamma. Also reported is preliminary cell based data suggesting the use of these compounds in the treatment of osteoporosis.
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| http://dx.doi.org/10.1016/j.bmcl.2006.08.003 | DOI Listing |
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