The basic physical properties of homogeneous membranes are relatively well known, while the effects of inhomogeneities with membranes are very much an active field of study. In this paper, a biphasic lipid vesicle with membrane embedded proteins is investigated. To take into account the influences of the proteins, a simple phenomenological coupling between the local fraction of proteins and the mean curvature square is suggested. By minimizing the energy of system, the E-L equations and boundary conditions are obtained and solved analytically for vesicle with a simple shape. Besides, stability phase diagrams and stability factor are put forward by linear perturbation analysis. Our results show two different situations which are strongly dependent on the nature of the proteins: a regime of easy instability when the proteins are strongly coupled to the membrane and a regime of difficult instability.
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http://dx.doi.org/10.1016/j.jbiomech.2006.06.015 | DOI Listing |
Plast Reconstr Surg Glob Open
December 2024
Department of Plastic, Reconstructive and Regenerative Surgery, Graduate School of Medicine, Nippon Medical School, Bunkyo Ward, Tokyo, Japan.
Background: Almost half of all spontaneously occurring keloids are acne keloids on the anterior chest. These keloids often grow in a crab-claw shape due to predominant tractional stresses on the scar; such stresses are risk factors for keloid growth/progression. To understand the relationship between acne keloid growth and mechanical stress, we conducted finite element analysis (FEA), measured the long/short dimensions of photographed acne keloids, and subjected acne keloids to microscopy.
View Article and Find Full Text PDFInt J Pharm
December 2024
Heinrich Heine University Duesseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutics and Biopharmaceutics, Universitätsstraße 1, Duesseldorf 40225, Germany. Electronic address:
Transdermal drug delivery using microneedle array patches has been investigated using a wide range of drug substances. Inkjet printing and micromolding are established methods for the production of microneedle array patches and both were used to combine lisinopril embedded in povidone and ibuprofen in Eudragit® RS / RL in a single patch. Dissolution studies, visual inspection, mechanical strength and insertion into an artificial skin membrane model were investigated.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA.
Chronic wounds are prone to infections with multidrug-resistant bacteria, forming polymicrobial biofilms that limit treatment options and increase the risk of severe complications. Current cleansing options are insufficient to disrupt and remove tenacious biofilms; antibiotic treatments, on the other hand, often fall short against these biofilm-embedded bacteria. This study explores an non-antibiotic approach that extends beyond conventional porphyrin-based phototherapy by using blue light (BL) in conjunction with ferric ions (Fe(III)) to disrupt and eradicate biofilms.
View Article and Find Full Text PDFLangmuir
December 2024
Department of Chemistry, School of Energy Technology, Pandit Deendayal Energy University (PDEU), Gandhinagar 382426, Gujarat, India.
Numerous corporations have overlooked environmental regulations concerning wastewater treatment, leading to a worldwide issue regarding hazardous pollutant discharge, particularly dyes and heavy metal ions, into river sources. Various industries, with water, energy, and biological sectors, actively employ membranes. Membranes capable of showing flux, metal and dye sorption, and catalysis have been developed and are extensively used by functionalizing the pores of ultrafiltration, microfiltration, and nanofiltration membranes with responsive properties.
View Article and Find Full Text PDFJ Chem Theory Comput
December 2024
The Graduate University for Advanced Studies (SOKENDAI), 38 Nishigo-Naka, Myodaiji, Okazaki, Aichi 444-8585, Japan.
The light-harvesting complex II (LHCII) in green plants exhibits highly efficient excitation energy transfer (EET). A comprehensive understanding of the EET mechanism in LHCII requires quantum chemical, molecular dynamics (MD), and statistical mechanics calculations that can adequately describe pigment molecules in heterogeneous environments. Herein, we develop MD simulation parameters that accurately reproduce the quantum mechanical/molecular mechanical energies of both the ground and excited states of all chlorophyll (Chl) molecules in membrane embedded LHCII.
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