AI Article Synopsis
- Phosphoinositide signaling molecules play crucial roles in various cellular processes such as growth, differentiation, and intracellular transport.
- The inositol polyphosphate 5-phosphatase family consists of ten enzymes that modify specific phosphoinositides, affecting functions like vesicle recycling and insulin signaling.
- The paper emphasizes recent research on two well-studied 5-phosphatases (OCRL and SHIP2) and introduces newly identified members (SKIP and PIPP), showcasing the complexity and diverse roles of this enzyme family.
Article Abstract
Phosphoinositide signaling molecules control cellular growth, proliferation and differentiation, intracellular vesicle trafficking, and cytoskeletal rearrangement. The inositol polyphosphate 5-phosphatase family remove the D-5 position phosphate from PtdIns(3,4,5)P3, PtdIns(4,5)P2 and PtdIns(3,5)P2 forming PtdIns(3,4)P2, PtdIns(4)P and PtdIns(3)P respectively. This enzyme family, comprising ten mammalian members, exhibit seemingly non-redundant functions including the regulation of synaptic vesicle recycling, hematopoietic cell function and insulin signaling. Here we highlight recently established insights into the functions of two well characterized 5-phosphatases OCRL and SHIP2, which have been the subject of extensive functional studies, and the characterization of recently identified members, SKIP and PIPP, in order to highlight the diverse and complex functions of this enzyme family.
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| http://dx.doi.org/10.1080/15216540600871159 | DOI Listing |
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