We present a virtual reality simulator to realize interventional radiology (IR) procedures remotely. The simulator contains two subsystems: one at the local site and the other at the remote site. At the local site, the interventional radiologist interacts with a three-dimensional (3-D) vascular model extracted from the patient's data and inserts IR devices through the Motion Tracking Box (MTB), which converts physical motion (translation and rotation) of IR devices into digital signal. This signal is transferred to the Actuator Box (AB) at the remote site that drives the IR devices in the patient. The status of the IR devices is subsequently fed back to the local site and displayed on the vascular model. To prove the concept, the prototype developed employs a physical angiography phantom (mimicking the patient) and its corresponding 3-D digital model. A magnetic tracking system provides information about positioning of the IR devices in the phantom. The initial results are encouraging. The AB controlled remotely drives IR devices with resolution of 0.00288 mm/step in translation and 0.079 deg/step in rotation.
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http://dx.doi.org/10.1109/TBME.2006.873762 | DOI Listing |
Cerebellum
January 2025
Department of Neuroscience and Physiology, Grossman School of Medicine, NYU Neuroscience Institute, New York University, New York, NY, 10016, USA.
Cerebellar transcranial alternating current stimulation (ctACS) has the potential to be an appealing, non-invasive treatment option for psychiatric and neurological disorders. However, realization of this potential has been limited by gaps in our knowledge of how ctACS affects cerebellar output on single cell and population levels. Previously, we showed that AC stimulation applied to the cerebellar surface produced a strong, frequency-dependent modulation of Purkinje cell (PC) and cerebellar nuclear (CN) cell activity.
View Article and Find Full Text PDFAm J Physiol Gastrointest Liver Physiol
January 2025
Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
This study aimed to determine if local injection of CXCL12 reduces sphincter fibrosis, restores sphincter muscle content, vascularization, and innervation, and recruits progenitor cells in a rabbit model of anal sphincter injury and incontinence. Adult female rabbits were assigned to 3 groups: uninjured/no treatment (control), injured/treated (treated), and injured/no treatment (untreated) (n=4 each). Injured groups were anesthetized and a section of external anal sphincter was removed at the 9:00 o'clock position.
View Article and Find Full Text PDFCell Mol Neurobiol
January 2025
Neuroscience Department, International School for Advanced Studies (SISSA), Via Bonomea 265, Trieste, TS, Italy.
In clinics, physical injuries to the spinal cord cause a temporary motor areflexia below lesion, known as spinal shock. This topic is still underexplored due to the lack of preclinical spinal cord injury (SCI) models that do not use anesthesia, which would affect spinal excitability. Our innovative design considered a custom-made micro impactor that provides localized and calibrated strikes to the ventral surface of the thoracic spinal cord of the entire CNS isolated from neonatal rats.
View Article and Find Full Text PDFPhytopathology
January 2025
LSU AgCenter, 302 Life Science Building, Baton Rouge, Louisiana, United States, 70803;
and are major pests of sweetpotato. The ability of to cause symptoms and reproduce on nematode-resistant cultivars threatens the sweetpotato industry. To evaluate the penetration, development, and reproduction of and on sweetpotato, a time-course study was conducted using the genotypes 'LA14-31' (resistant to and intermediate-resistant to ), 'LA18-100' (susceptible to and resistant to ), and 'LA19-65' (resistant to and susceptible to ), with 'Beauregard' (susceptible to both species) and 'Jewel' (resistant to and intermediate-resistant to ) as controls.
View Article and Find Full Text PDFAutophagy
January 2025
Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Lysosomes are the major cellular organelles responsible for nutrient recycling and degradation of cellular material. Maintenance of lysosomal integrity is essential for cellular homeostasis and lysosomal membrane permeabilization (LMP) sensitizes toward cell death. Damaged lysosomes are repaired or degraded via lysophagy, during which glycans, exposed on ruptured lysosomal membranes, are recognized by galectins leading to K48- and K63-linked poly-ubiquitination (poly-Ub) of lysosomal proteins followed by recruitment of the macroautophagic/autophagic machinery and degradation.
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