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Descriptive analysis of adverse events following immunization with oral cholera vaccine in Lebanon.
Front Public Health
December 2024
Quality Assurance of Pharmaceutical Products Department, National Pharmacovigilance Program, Lebanese Ministry of Public Health, Beirut, Lebanon.
Background: A national Oral Cholera Vaccine (OCV) Euvichol-Plus® campaign was launched in Lebanon, in response to the first outbreak in three decades, recorded in October 2022. The OCV vaccination campaign was carried out between November 2022 and February 2023. This study aims to cover adverse events reports, received at the Lebanese National Pharmacovigilance Program's (LNPVP) passive surveillance system.
View Article and Find Full Text PDFStructural analysis of the siderophore-interacting protein from Vibrio anguillarum and its implications in classification of Vibrio homologs.
Biochem Biophys Res Commun
December 2024
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:
Bacteria secrete siderophores to sequester the scarce iron in the environments, then the iron is transported into the cell in a siderophore-complexed form, which can be released by siderophore-interacting protein (SIP). Vibrio species comprise an array of serious pathogens, whose iron releasing process by SIP remains poorly understood. Herein, we report the high-resolution (1.
View Article and Find Full Text PDFUnveiling the anti-giardial properties of Andrographis paniculata leaf extract through in vitro studies.
Trop Biomed
September 2024
Division of Parasitology, ICMR-National Institute of Cholera and Enteric Diseases (ICMR-NICED), India.
Article Synopsis
- * Current treatments are limited due to side effects and drug resistance, highlighting the need for alternative therapies.
- * This study investigated Andrographis paniculata leaf extract, which showed significant effectiveness in killing Giardia trophozoites, suggesting it could be a viable, natural treatment option with fewer side effects.
Biochemical Modulators of Tight Junctions (TJs): Occludin, Claudin-2 and Zonulin as Biomarkers of Intestinal Barrier Leakage in the Diagnosis and Assessment of Inflammatory Bowel Disease Progression.
Molecules
September 2024
Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
Article Synopsis
- - The study highlights the urgent need for non-invasive biomarkers for the early diagnosis of inflammatory bowel disease (IBD), focusing on the serum levels of occludin, claudin-2, and zonulin in patients undergoing treatment.
- - Key findings indicate that levels of occludin decreased and claudin-2 increased in IBD patients compared to healthy individuals; zonulin levels also rose in Crohn’s disease patients, showing promising diagnostic capabilities.
- - Treatment with the TNF-α inhibitor adalimumab improved biomarker levels in ulcerative colitis patients, suggesting potential for these markers as effective tools in diagnosing and monitoring IBD.
First Report of a Fatal Septicaemia Case Caused by Vibrio metoecus: A Comprehensive Functional and Genomic Study.
J Infect Dis
October 2024
Departamento de Microbiología y Ecología, & Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València. Burjassot, Valencia, Spain.
Article Synopsis
- A recent surge in vibriosis linked to global warming highlights a new species, Vibrio metoecus, which has not previously been associated with human septicemia deaths.
- A blood isolate from a patient who died from secondary septicemia was identified through advanced genome sequencing techniques after traditional methods failed.
- The study found that V. metoecus can survive in human serum and carries unique genetic traits related to surface polysaccharide modification, emphasizing the need to monitor emerging pathogens as climate change may enhance their risks.
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