AI Article Synopsis
- A study was conducted to boost the production of pristinamycin by using batch fermentation with Streptomyces pristinaespiralis and adsorbent resins.
- The polymeric resin JD-1 was determined to be the most effective due to its adsorption and desorption properties.
- The addition of 12% JD-1 resin at 20 hours into the fermentation process increased pristinamycin production from 0.4 g/l to 1.13 g/l in flasks and from 0.64 g/l to 0.8 g/l in a 3-liter bioreactor.
Article Abstract
Batch fermentation by Streptomyces pristinaespiralis with the addition of adsorbent resins was used to increase the production of pristinamycin. In consideration of the adsorption capacity and the desorption ability, a polymeric resin, JD-1, was finally selected. The maximum production of pristinamycin in Erlenmeyer flasks went up to 1.13 from 0.4 g l(-1), by adding 12% (w/v) resin JD-1 into the culture broth at 20 h after inoculation. In a 3 l bioreactor, pristinamycin fermentation with the addition of 12% (w/v) resin JD-1 at 20 h after inoculation reached 0.8 g l(-1), which was a 1.25-fold increase over fermentation without resin.
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| http://dx.doi.org/10.1007/s10529-006-9157-9 | DOI Listing |
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