We describe various techniques to synthesize three types of computer-generated hologram (CGH): the Fresnel-Fourier CGH, the Fresnel CGH, and the image CGH. These holograms are synthesized by fusing multiple perspective views of a computer-generated scene. An initial hologram is generated in the computer as a Fourier hologram. Then it can be converted to either a Fresnel or an image hologram by computing the desired wave propagation and imitating an interference process of optical holography. By illuminating the CGH, a 3D image of the objects is constructed. Computer simulations and experimental results underline the performance of the suggested techniques.
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http://dx.doi.org/10.1364/ao.45.006533 | DOI Listing |
EXCLI J
November 2024
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.
The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal point of cancer research. This literature review delves into the complex interplay between the tumor suppressor protein p53 and its main regulator MDM2, highlighting their interaction and implications in cancer development and progression. The review compiles and summarizes the existing understanding of the biology and regulation of p53 and MDM2, emphasizing their roles in various cellular processes, including cell cycle regulation, DNA repair, apoptosis, and metabolism.
View Article and Find Full Text PDFNeurons use cell-adhesion molecules (CAMs) to interact with other neurons and the extracellular environment: the combination of CAMs specifies migration patterns, neuronal morphologies, and synaptic connections across diverse neuron types. Yet little is known regarding the intracellular signaling cascade mediating the CAM recognitions at the cell surface across different neuron types. In this study, we investigated the neural developmental role of Afadin , a cytosolic adapter protein that connects multiple CAM families to intracellular F-actin.
View Article and Find Full Text PDFNuclear DNA is organized into a compact three-dimensional (3D) structure that impacts critical cellular processes. High-throughput chromosome conformation capture (Hi-C) is the most widely used method for measuring 3D genome architecture, while linear epigenomic assays, such as ATAC-seq, DNase-seq, and ChIP-seq, are extensively employed to characterize epigenomic regulation. However, the integrative analysis of chromatin interactions and associated epigenomic regulation remains challenging due to the pairwise nature of Hi-C data, mismatched resolution between Hi-C and epigenomic assays, and inconsistencies among analysis tools.
View Article and Find Full Text PDFFront Behav Neurosci
December 2024
Department of Mathematics, University of Texas at Arlington, Arlington, TX, United States.
Introduction: Sustaining attention is a notoriously difficult task as shown in a recent experiment where reaction times (RTs) and pupillometry data were recorded from 350 subjects in a 30-min vigilance task. Subjects were also presented with different types of goal, feedback, and reward.
Methods: In this study, we revisit this experimental data and solve three families of machine learning problems: (i) RT-regression problems, to predict subjects' RTs using all available data, (ii) RT-classification problems, to classify responses more broadly as attentive, semi-attentive, and inattentive, and (iii) to predict the subjects' experimental conditions from physiological data.
Cereb Cortex
January 2025
Department of Clinical Psychology, The First People's Hospital of Yunnan Province of the Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650223, China.
Childhood maltreatment (CM) is a major risk factor for numerous mental disorders. The long-term consequences of CM on brain structural and functional plasticity have been well documented. However, the neurophysiological biotypes of CM remain unclear although the childhood trauma questionnaire uses different dimensions to assess trauma types.
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