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Similar Publications
Article Synopsis
- HIV significantly affects neurocognitive function in Africa, leading to high prevalence rates of neurocognitive disorders, with Central and South Africa showing the highest impairment levels (around 49.33%).
- Variability in neurocognitive impairment prevalence is influenced by factors like ART availability, healthcare infrastructure, and co-infections, emphasizing the need for targeted interventions.
- Addressing this issue requires collaboration among healthcare providers, policymakers, and communities, focusing on education, early detection, improved resources, and research partnerships to better support individuals living with HIV.
Clustering of cognitive domains among older persons with HIV.
Gac Med Mex
November 2024
Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Article Synopsis
- - The study investigated the cognitive profiles of older people with HIV (OPWH) undergoing combined antiretroviral therapy, focusing on how age interacts with HIV-related cognitive disorders.
- - Researchers conducted a cross-sectional analysis of 330 OPWH aged 50 and older, using neuropsychological tests to evaluate cognitive functions and identify clusters of cognitive impairment.
- - Results showed three distinct cognitive clusters: one with significant memory impairments, another with language and abstraction issues, and a third with no specific domain impairments, suggesting variations based on both HIV-related and other individual factors.
Accelerated cognitive aging in chronically infected HIV-1 positive individuals despite effective long-term antiretroviral therapy.
Metab Brain Dis
November 2024
Department of Virology and Biotechnology, ICMR-National Institute for Research in Tuberculosis, Chennai, 600031, India.
Article Synopsis
- * A study conducted in Chennai found that 71% of virally suppressed PLHIV showed significant neurocognitive impairment, despite long-term adherence to antiretroviral therapy and undetectable viral loads.
- * The research revealed changes in proteins and metabolites linked to neuroinflammation and cognitive decline, emphasizing the need for targeted intervention strategies for improving long-term management of HIV-infected individuals.
Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice.
Life Sci Alliance
February 2025
School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA
Article Synopsis
- * A study using murine models showed that the presence of the Nef protein in HIV increases neuroinflammation and damages brain structures compared to Nef-deficient strains.
- * Findings suggest that Nef plays a key role in worsening neuronal injury and may guide future research on HAND mechanisms and treatments.
Unearthing Influenza's Unusual Neurological Impact.
Cureus
November 2024
Acute Medicine, Northern Lincolnshire and Goole NHS Foundation Trust, Scunthorpe, GBR.
Article Synopsis
- Influenza is a viral infection that mainly targets the respiratory system but can also lead to neurological issues like cognitive impairment and seizures.
- A case study involving a middle-aged male showed flu-like symptoms followed by peripheral neuropathy, with extensive tests revealing no other causes except for Influenza A.
- The patient responded well to conservative treatment, suggesting that his neuropathy was likely caused by the influenza infection.
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