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Decision making in surgery: honoring patient autonomy despite high mortality risk in a 36-year-old woman with endocarditis.
J Surg Case Rep
March 2025
Department of Palliative Care, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
Infective endocarditis (IE) is a common complication in patients who inject drugs. We present the case of a 36-year-old woman with IE affecting both the aortic and tricuspid valves, along with a cardiac implantable electronic device infection, 11 weeks after combined aortic valve replacement, tricuspid valve replacement, and pacemaker implantation. The patient declined the medically indicated cardiac surgery due to her recent taxing surgical and rehabilitation experiences.
View Article and Find Full Text PDFFully degradable, transparent, and flexible photodetectors using ZnO nanowires and PEDOT:PSS based nanofibres.
Npj Flex Electron
March 2025
Bendable Electronics and Sustainable Technologies (BEST) Group, Northeastern University, Boston, MA 02115 USA.
Transparent light detection devices are attractive for emerging see-through applications such as augmented reality, smart windows and optical communications using light fidelity (Li-Fi). Herein, we present flexible and transparent photodetectors (PDs) using conductive poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS): Ag nanowires (NWs) based nanofibres and zinc oxide (ZnO) NWs on a transparent and degradable cellulose acetate (CA) substrate. The electrospun (PEDOT:PSS): Ag NW-based nanofibres exhibit a sheet resistance of 11 Ω/sq and optical transmittance of 79% (at 550 nm of wavelength).
View Article and Find Full Text PDFAltered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes.
Front Physiol
February 2025
Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Introduction: The leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia. Previous studies have shown that T2DM-induced functional remodeling of cardiac vagal postganglionic (CVP) neurons contributes to ventricular arrhythmogenesis. As leptin resistance is common in T2DM patients, and CVP neurons are located in epicardial adipose pads, a tissue that secretes leptin, in this study we aimed to elucidate a correlation between leptin resistance and CVP neuronal dysfunction in T2DM.
View Article and Find Full Text PDFA non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats.
Front Vet Sci
February 2025
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Introduction: Human frailty has long been studied and dozens of "frailty scales" have been developed, but equivalent research is more limited in cats. This pilot study aimed to determine the feasibility of recruiting and retaining veterinary practices and owners, collecting study data, and analyzing results about frailty in older cats.
Methods: Participating feline-exclusive practice veterinarians recruited cats aged 11-20 years, of either sex and of any breed.
Evolutionary and epidemic dynamics of COVID-19 in Germany exemplified by three Bayesian phylodynamic case studies.
Bioinform Biol Insights
March 2025
Transmission, Infection, Diversification & Evolution Group (tide), Max Planck Institute of Geoanthropology, Jena, Germany.
The importance of genomic surveillance strategies for pathogens has been particularly evident during the coronavirus disease 2019 (COVID-19) pandemic, as genomic data from the causative agent, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), have guided public health decisions worldwide. Bayesian phylodynamic inference, integrating epidemiology and evolutionary biology, has become an essential tool in genomic epidemiological surveillance. It enables the estimation of epidemiological parameters, such as the reproductive number, from pathogen sequence data alone.
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