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The role of OCT4 and CD44 in lower lip carcinogenesis.
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Department of Dentistry, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Purpose: Carcinogenesis is characterized by the transformation of normal cells into malignant cells. Concerning the lower lip, exposure to UV radiation is the main etiological factor associated with the development of epidermoid carcinomas and actinic cheilitis. According to the hierarchical model theory, cancer development is driven by populations of cancer stem cells.
View Article and Find Full Text PDFGeneration of glucosylantimycins by heterologous expression of a promiscuous glycosyltransferase in a deepsea-derived .
Nat Prod Res
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Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Antimycins are a class of depsipeptide compounds that exhibit diverse bioactivities. However, their potential clinical applications are hampered by high cell toxicities. Glycosylation usually has profound impacts on the physicochemical properties, bioactivities and toxicities of natural products.
View Article and Find Full Text PDFDistribution Characteristics in Clinical Phenotype and Immunohistochemistry of STK11 Adnexal Tumors: Case Report and Narrative Synthesis.
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January 2025
Department of Pathology, the Second Hospital of Jilin University, Changchun, Jilin, China.
adnexal tumors are recently named tumors of the female adnexal region, associated with Peutz-Jeghers syndrome (PJS). There is a lack of studies on the clinical phenotypes of PJS concerning the pathology and molecular characteristics of adnexal tumors. We searched for 781 relevant studies through PubMed and Web of Science, and preliminary statistical and grouping comparisons were made using the screened study data combined with our patient.
View Article and Find Full Text PDFIdentification of pennaceous barbule cell factor (PBCF), a novel gene with spatiotemporal expression in barbule cells during feather development.
Gene
January 2025
Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Kitaku, Tsushimanaka, Okayama 700-8530, Japan; Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, 3-1-1 Kitaku, Tsushimanaka, Okayama 700-8530, Japan. Electronic address:
Bird contour feathers exhibit a complex hierarchical structure composed of a rachis, barbs, and barbules, with barbules playing a crucial role in maintaining feather structure and function. Understanding the molecular mechanisms underlying barbule formation is essential for advancing our knowledge of avian biology and evolution. In this study, we identified a novel gene, pennaceous barbule cell factor (PBCF), using microarray analysis, RT-PCR, and in situ hybridization.
View Article and Find Full Text PDFHigh-yield soluble production of recombinant β-keratin from Gallus gallus feathers using an experimental design approach.
J Biotechnol
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Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Bioquímica, Rio de Janeiro, RJ, Brazil. Electronic address:
The search for new non-animal textile materials has increased yearly as environmental awareness and veganism continue to spread, driving the development of greener fabrics. Concurrently, β-keratin, a fibrous, resistant, and insoluble protein shows great potential for producing innovative biomaterials. However, β-keratin is naturally abundant in animal feathers.
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