Objectives: To determine the deterioration in the maximal active deflection and flow capabilities of a new-generation flexible ureteroscope (URS).
Methods: We performed 50 ureterorenoscopies using the same URS: a Karl Storz 11278 AU1 Flex-X, which is capable of a 270 degree active deflection in the ventral and dorsal directions. Postoperatively, we evaluated the maximal active ventral and dorsal deflection, irrigation flow at 100 cm H2O, and the number of broken optical fibers.
Results: The URS was used for a total of 76 hours, 15 minutes (average 95 minutes per procedure). The maximal ventral deflection had deteriorated from 270 degrees to 208 degrees at the last procedure. The maximal dorsal deflection had decreased from 270 degrees to 133 degrees. The irrigation flow at 100 cm H2O had decreased from 50 mL/min initially to 40 mL/min at the last procedure. The number of broken image fibers had reached six at the 50th procedure. One repair was necessary at the 50th procedure because of a laser perforation of the working channel.
Conclusions: The need for repair occurs less frequently with the new-generation of URSs, especially when they are used by an experienced endourologist. In the future, improvements in the durability of the flexible URS will still be key for widespread use of the technique and especially to limit damage by the laser to the working channel.
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http://dx.doi.org/10.1016/j.urology.2006.02.043 | DOI Listing |
Mater Horiz
January 2025
School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, 230026, P. R. China.
Hydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving large-scale production with excellent mechanical properties required to withstand multiple cycles of mechanical loads while maintaining high electrochemical performance needed for the new-generation flexible zinc-ion batteries. Herein, we present a superspreading-based strategy to produce robust hydrogel electrolytes consisting of polyvinyl alcohol, sodium alginate and sodium acetate.
View Article and Find Full Text PDFSci Bull (Beijing)
December 2024
State Key Laboratory of Advanced Fiber Materials, Institute of Functional Materials, College of Materials Science and Engineering, Research Base of Textile Materials for Flexible Electronics and Biomedical Applications (China Textile Engineering Society), Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Shanghai Key Laboratory of Lightweight Composite, Donghua University, Shanghai 201620, China. Electronic address:
It remains a challenge for a simple and scalable method to fabricate ultrathin porous Janus membranes for stretchable on-skin electronics. Here, we propose a one-step droplet spreading phase separation strategy to prepare an ultrathin and easily collected Janus thermoplastic polyurethane (TPU) membrane within seconds. The metal-ion solvation structure mitigated migration kinetics to delay TPU solution demixing, promoting the further penetration of the coagulating solvent.
View Article and Find Full Text PDFNatl Sci Rev
February 2025
Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China.
Ion exchange membranes (IEMs) enable fast and selective ion transport and the partition of electrode reactions, playing an important role in the fields of precise ion separation, renewable energy storage and conversion, and clean energy production. Traditional IEMs form ion channels at the nanometer-scale via the assembly of flexible polymeric chains, which are trapped in the permeability/conductivity and selectivity trade-off dilemma due to a high swelling propensity. New-generation IEMs have shown great potential to break this intrinsic limitation by using microporous framework channels for ion transport under a confinement regime.
View Article and Find Full Text PDFNat Commun
January 2025
School of Artificial Intelligence and Data Science, University of Science and Technology of China, Hefei, China.
Two-dimensional (2D) van der Waals heterostructures consist of different 2D crystals with diverse properties, constituting the cornerstone of the new generation of 2D electronic devices. Yet interfaces in heterostructures inevitably break bulk symmetry and structural continuity, resulting in delicate atomic rearrangements and novel electronic structures. In this paper, we predict that 2D interfaces undergo "spontaneous curvature", which means when two flat 2D layers approach each other, they inevitably experience out-of-plane curvature.
View Article and Find Full Text PDFNano Lett
January 2025
School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China.
cGAS-STING pathway activation has attracted considerable attention in antitumor immunotherapy, but clinical outcomes lag behind expectations due to overlooked negative feedback mechanisms. Here, we determine that STING activation promotes tumor stemness, which weakens the efficacy of STING-based therapies, presenting a double-edged sword. To address this therapeutic paradox, a simple metal-phenolic polymeric micelle (HMQ) was developed, in which Mn (a STING agonist) is coordinated with quercetin (a stemness inhibitor) and hyaluronic acid (HA), to unlock the full therapeutic potential of the cGAS-STING pathway.
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