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A Self-Priming Pyroptosis-Inducing Agent for Activating Anticancer Immunity.
Adv Healthc Mater
March 2025
Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Pyroptosis, a form of programmed cell death mediated by the gasdermin family, has emerged as a promising strategy for inducing anti-tumor immunity. However, efficiently inducing pyroptosis in tumor cells remains a significant challenge due to the limited activation of key mediators like caspases in tumor tissues. Herein, a self-priming pyroptosis-inducing agent (MnNZ@OMV) is developed by integrating outer membrane vesicles (OMVs) with manganese dioxide nanozymes (MnNZ) to trigger pyroptosis in tumor cells.
View Article and Find Full Text PDFMolecular Basis of Impaired Decidualization in the Eutopic Endometrium of Endometriosis Patients.
Cells
February 2025
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología (INPer)-Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City 11000, Mexico.
Endometriosis is a chronic gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. A common feature of this pathology is the impaired decidualization of endometrial stromal cells, a critical process that prepares the uterus for embryo implantation. This decidualization defect has been mechanistically linked to progesterone resistance in endometriotic lesions.
View Article and Find Full Text PDFAdvancing Peri-Implantitis Treatment: A Scoping Review of Breakthroughs in Implantoplasty and Er:YAG Laser Therapies.
Clin Exp Dent Res
February 2025
Department of Periodontics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background: Peri-implantitis represents a significant challenge in dental implantology, characterized by inflammatory reactions around osseointegrated dental implants that lead to progressive alveolar bone loss.
Objectives: To generate a scoping review that evaluates the efficacy of implantoplasty and Er:YAG laser therapies in managing peri-implantitis by synthesizing recent evidence on their impact on key clinical parameters-including probing depth reduction, bleeding on probing improvement, and marginal bone level stabilization-and to explore the potential synergistic benefits of combining these modalities for enhanced treatment outcomes.
Material And Methods: A comprehensive search was conducted in PubMed, EMBASE, the Cochrane Library, and Web of Science for studies published from January 2018 to the present.
Design of a Soft Robotic Artificial Cardiac Wall.
Artif Organs
March 2025
The BioRobotics Insitute and Department of Excellence of Robotics & AI, Scuola Superiore Sant'Anna, Pontedera, Italy.
Background: In cardiovascular engineering, the recent introduction of soft robotic technologies sheds new light on the future of implantable cardiac devices, enabling the replication of complex bioinspired architectures and motions. To support human heart function, assistive devices and total artificial hearts have been developed. However, the system's functionality, hemocompatibility, and overall implantability are still open challenges.
View Article and Find Full Text PDFCOMPARISON OF STENT GEOMETRY ACHIEVED BY DIFFERENT SIDE-BRANCH BALLOONING TECHNIQUES FOR BIFURCATION PROVISIONAL STENTING: THE CRABBIS TRIAL.
JACC Cardiovasc Interv
March 2025
Department of Cardiovascular and Pulmonary Sciences, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Electronic address:
Background: "Stepwise provisional stenting" is the most adopted approach for percutaneous coronary interventions (PCI) in bifurcation lesions. During these procedures, side-branch (SB) may deserve treatment, but the best ballooning technique is still undetermined.
Objectives: To compare the stent configurations obtained by two SB ballooning sequences after the main vessel (MV) stent implantation: proximal-optimization-technique (POT)+kissing-balloon-inflation+final POT (PKP) versus POT+isolated-SB-dilation+final POT (PSP).
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