Objective: The objective of this study was to determine serum (perfluorooctanoate [PFOA]) in residents near a fluoropolymer production facility: the contributions from air, water, and occupational exposures, personal and dietary habits, and relationships to age and gender.

Methods: The authors conducted questionnaire and serum PFOA measurements in a stratified random sample and volunteers residing in locations with the same residential water supply but with higher and lower potential air PFOA exposure.

Results: Serum (PFOA) greatly exceeded general population medians. Occupational exposure from production processes using PFOA and residential water had additive effects; no other occupations contributed. Serum (PFOA) depended on the source of residential drinking water, and not potential air exposure. For public water users, the best-fit model included age, tap water drinks per day, servings of home-grown fruit and vegetables, and carbon filter use.

Conclusions: Residential water source was the primary determinant of serum (PFOA).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038253PMC
http://dx.doi.org/10.1097/01.jom.0000232486.07658.74DOI Listing

Publication Analysis

Top Keywords

serum pfoa
16
residential water
12
potential air
8
water
7
serum
6
pfoa
6
community exposure
4
exposure perfluorooctanoate
4
perfluorooctanoate relationships
4
relationships serum
4

Similar Publications

Construction of the cancer patients' database based on the US National Health and Nutrition Examination Survey (NHANES) datasets for cancer epidemiology research.

BMC Med Res Methodol

January 2025

Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 07441, South Korea.

Background: The US National Health and Nutrition Examination Survey (NHANES) dataset does not include a specific question or laboratory test to confirm a history of cancer diagnosis. However, if straightforward variables for cancer history are introduced, US NHANES could be effectively utilized in future cancer epidemiology studies. To address this gap, the authors developed a cancer patient database from the US NHANES datasets by employing multiple R programming codes.

View Article and Find Full Text PDF

Perfluoroalkyl chemicals are one of the most stable substances in industry and have become ubiquitous contaminants owing to their persistence in the environment. This study enrolled 1,953 participants aged ≥40 years old using data from the National Health and Nutrition Examination Survey (NHANES). We selected four perfluoroalkyl chemicals with a detection frequency of more than 80%, including perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonic acid (PFOS).

View Article and Find Full Text PDF

Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020.

Environ Res

January 2025

Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address:

Per- and polyfluoroalkyl substances (PFAS), also known as "forever chemicals" because of their persistence in the environment, have been used in many commercial applications since the 1940s. Of late, the detection of PFAS in drinking water throughout the United States has raised public and scientific concerns. To understand PFAS exposure trends in the general U.

View Article and Find Full Text PDF

PFAS concentrations in the blood of Danish surfers.

Int J Hyg Environ Health

January 2025

Department of Occupational and Environmental Medicine, Danish Ramazzini Centre, Aalborg University Hospital, Havrevangen 1, 9000, Aalborg C, Denmark; Department of Clinical Medicine, Aalborg University, Selma Lagerløftsvej 249, 9260, Aalborg, Denmark.

Background: Per- and poly-fluoroalkyl Substances (PFAS) have been used for decades in countless households and industrial products. Many PFAS do not degrade and are thus ubiquitous in the environment and within organisms. Humans are primarily exposed to PFAS through ingestion and inhalation, and such exposure has been associated with several health effects.

View Article and Find Full Text PDF

Background: Few studies have investigated associations between per- and polyfluoroalkyl substances (PFAS) and childhood cancers. Detectable levels of PFAS in California water districts were reported in the Third Unregulated Contaminant Monitoring Rule for 2013-2015.

Methods: Geocoded residences at birth were linked to corresponding water district boundaries for 10,220 California-born children (aged 0-15 years) diagnosed with cancers (2000-2015) and 29,974 healthy controls.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!