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The Circadian Response to Evening Light Spectra in Early Childhood: Preliminary Insights.
J Biol Rhythms
January 2025
Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.
Although the sensitivity of the circadian system to the characteristics of light (e.g., biological timing, intensity, duration, spectrum) has been well studied in adults, data in early childhood remain limited.
View Article and Find Full Text PDFDynamical robustness of a Boolean model for the human gonadal sex determination.
Comput Biol Chem
December 2024
Facultad de Ingeniería y Ciencias, Univ. Adolfo Ibáñez, Av. Diagonal Las Torres 2700, Peñalolen, Santiago, Chile; Center of Applied Ecology and Sustainability (CAPES), Santiago, Chile; Millennium Nucleus for the Development of Super Adaptable Plants (MN-SAP), Santiago, Chile.
Gonadal sex determination (GSD) is a complex but poorly understood process in the early stages of embryonic development. This process determines whether the bipotential gonadal primordium (BGP) will differentiate into testes or ovaries through the activation of genetic factors related to Sertoli or Granulosa cells, respectively. The study of this developmental process remains challenging due to experimental limitations and the complexity of the underlying genetic interactions.
View Article and Find Full Text PDFComputational Analyses Reveal Deregulated Clock Genes Associated with Breast Cancer Development in Night Shift Workers.
Int J Mol Sci
August 2024
Department of Biomedical and Dental Sciences, Morphological and Functional Imaging, Section of Occupational Medicine, University of Messina, 78712 Messina, Italy.
Breast cancer (BC) is the leading cause of cancer death among women worldwide. Women employed in shift jobs face heightened BC risk due to prolonged exposure to night shift work (NSW), classified as potentially carcinogenic by the International Agency for Research on Cancer (IARC). This risk is linked to disruptions in circadian rhythms governed by clock genes at the cellular level.
View Article and Find Full Text PDFMitigating time toxicity in lymphoma and multiple myeloma.
Leuk Lymphoma
October 2024
Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Article Synopsis
- Time toxicity in cancer treatment means that too many doctor visits and treatments can hurt how patients feel and live their lives.
- The review looks at how this affects patients with non-Hodgkin lymphoma and multiple myeloma, especially when choosing treatments like chemo or specific drugs.
- It also discusses ways to reduce these burdens while still keeping the treatments effective and safe for patients.
The feasibility of using ecological momentary assessment to understand urinary and fecal incontinence experiences in adults with spina bifida: A 30-day study.
PLoS One
December 2023
Division of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana.
In this paper, we evaluate the feasibility of using ecological momentary assessment (EMA) to understand urinary (UI) and fecal (FI) incontinence in adults with spina bifida (SB). As part of a larger 30-day prospective study to understand the incontinence in adults with SB (N = 89), participants completed end-of-day EMA diaries assessing the frequency and context of UI and FI. We used these data to assess the method feasibility across six dimensions: (a) compliance, or data entry which is consistent with study protocol and substantially complete; (b) reactivity, or behavior change attributed to study participation; (c) participant acceptability, or convenience and ease of method beneficial to compliance; (d) data capture, or the volume of incontinence behaviors collected; (e) the accuracy of incontinence reports; and f) participant-provided feedback for future studies.
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