AI Article Synopsis
- A young girl experienced temporary deafness related to increased body temperature, prompting a series of audiological and neurologic tests.
- The audiological evaluations showed a temporary bilateral hearing loss with normal outer hair cell function but abnormal responses in the auditory brain stem when her temperature rose.
- This case highlights a rare condition called temperature-dependent auditory neuropathy, akin to Uhthoff's phenomenon, and adds valuable insights to the limited literature on this disorder.
Article Abstract
Objectives: We describe the case of a young girl in whom transient deafness occurred when her core body temperature rose.
Methods: The patient was referred for a series of audiological and neurologic evaluations performed over time in both afebrile and febrile states, as well as after a stress test (with a treadmill) in which the body temperature rise simulated the febrile state.
Results: The patient was found to have a temporary bilateral hearing loss, but had normal distortion product otoacoustic emissions. Moreover, auditory brain stem responses revealed the absence of neural synchrony when her core body temperature increased.
Conclusions: These results are consistent with a temperature-dependent auditory neuropathy, a rare condition in which patients show normal outer hair cell function and abnormal neural function of the eighth cranial nerve. The symptom is reminiscent of Uhthoff's phenomenon, which is described as transient visual loss and is usually observed in multiple sclerosis. This case of temperature-dependent auditory neuropathy is noteworthy because it sheds light on a disorder of which there have been few reports in the literature. We discuss its similarity to Uhthoff's phenomenon.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/000348940611500706 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Response of primary auditory neurons to stimulation with infrared light in vitro.
J Neural Eng
March 2021
Faculty of Science, Engineering and Technology, Swinburne University of Technology, John Street, Hawthorn VIC 3122, Australia.
Objective: Infrared light can be used to modulate the activity of neuronal cells through thermally-evoked capacitive currents and thermosensitive ion channel modulation. The infrared power threshold for action potentials has previously been found to be far lower in the in vivo cochlea when compared with other neuronal targets, implicating spiral ganglion neurons (SGNs) as a potential target for infrared auditory prostheses. However, conflicting experimental evidence suggests that this low threshold may arise from an intermediary mechanism other than direct SGN stimulation, potentially involving residual hair cell activity.
View Article and Find Full Text PDFA vascular mechanism to explain thermally mediated variations in deep-body cooling rates during the immersion of profoundly hyperthermic individuals.
Exp Physiol
April 2018
Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW, 2522, Australia.
New Findings: What is the central question of this study? Does the cold-water immersion (14°C) of profoundly hyperthermic individuals induce reductions in cutaneous and limb blood flow of sufficient magnitude to impair heat loss relative to the size of the thermal gradient? What is the main finding and its importance? The temperate-water cooling (26°C) of profoundly hyperthermic individuals was found to be rapid and reproducible. A vascular mechanism accounted for that outcome, with temperature-dependent differences in cutaneous and limb blood flows observed during cooling. Decisions relating to cooling strategies must be based upon deep-body temperature measurements that have response dynamics consistent with the urgency for cooling.
View Article and Find Full Text PDFEffect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex.
Pflugers Arch
December 2017
Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Tight coupling of neuronal metabolism to synaptic activity is critical to ensure that the supply of metabolic substrates meets the demands of neuronal signaling. Given the impact of temperature on metabolism, and the wide fluctuations of brain temperature observed during clinical hypothermia, we examined the effect of temperature on neurometabolic coupling. Intrinsic fluorescence signals of the oxidized form of flavin adenine dinucleotide (FAD) and the reduced form of nicotinamide adenine dinucleotide (NADH), and their ratios, were measured to assess neural metabolic state and local field potentials were recorded to measure synaptic activity in the mouse brain.
View Article and Find Full Text PDFStay tuned: active amplification tunes tree cricket ears to track temperature-dependent song frequency.
Biol Lett
April 2016
Department of Biological Sciences, University of Toronto at Scarborough, Scarborough, Canada M1C 1A4.
Tree cricket males produce tonal songs, used for mate attraction and male-male interactions. Active mechanics tunes hearing to conspecific song frequency. However, tree cricket song frequency increases with temperature, presenting a problem for tuned listeners.
View Article and Find Full Text PDFTemperature effects on the tympanal membrane and auditory receptor neurons in the locust.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
September 2014
Department of Biology, Behavioural Physiology Group, Humboldt-Universität zu Berlin, Invalidenstrasse 43, 10115, Berlin, Germany,
Poikilothermic animals are affected by variations in environmental temperature, as the basic properties of nerve cells and muscles are altered. Nevertheless, insect sensory systems, such as the auditory system, need to function effectively over a wide range of temperatures, as sudden changes of up to 10 °C or more are common. We investigated the performance of auditory receptor neurons and properties of the tympanal membrane of Locusta migratoria in response to temperature changes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!