Objective: To analyze the susceptibility genes of a Parkinson's Disease (PD) family.
Methods: The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.
Results: We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.
Conclusion: These 9 genes are not the susceptibility genes of PD in this family.
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