AI Article Synopsis
- The study investigated how injecting neuropeptide W-30 (NPW30) into the brain affects levels of plasma arginine vasopressin (AVP) and oxytocin (OXT) in rats.
- The results showed that plasma levels of both hormones rose significantly just 5 and 15 minutes after the NPW30 injection.
- Additionally, there was an increase in c-fos mRNA and AVP hnRNA production in specific brain regions over 15 to 60 minutes, indicating that NPW30 may play a role in regulating hormone secretion in these areas.
Article Abstract
We examined the effects of i.c.v. administration of neuro-peptide W-30 (NPW30) on plasma arginine vasopressin (AVP) and plasma oxytocin (OXT) using RIA. The induction of c-fos mRNA, AVP heteronuclear (hn)RNA, and c-Fos protein (Fos) in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of rats were also investigated using in situ hybridization histochemistry for c-fos mRNA and AVP hnRNA, and immunohistochemistry for Fos. Both plasma AVP and OXT were significantly increased at 5 and 15 min after i.c.v. administration of NPW30 (2.8 nmol/rat). In situ hybridization histochemistry revealed that the induction of c-fos mRNA and AVP hnRNA in the SON and PVN were significantly increased 15, 30, and 60 min after i.c.v. administration of NPW30 (1.4 nmol/rat). Dual immunostaining for Fos/AVP and Fos/OXT revealed that both AVP-like immunoreactive (LI) cells and OXT-LI cells exhibited nuclear Fos-LI in the SON and PVN, 90 min after i.c.v. administration of NPW30 (2.8 nmol/rat). These results suggest that central NPW30 may be involved in the regulation of secretion of AVP and OXT in the magnocellular neurosecretory cells in the SON and PVN.
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| http://dx.doi.org/10.1677/joe.1.06636 | DOI Listing |
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