AI Article Synopsis
- CF6 is identified as a new inhibitor of prostacyclin, showing significantly higher levels in patients with type 2 diabetes compared to healthy individuals.
- Higher CF6 levels are linked to elevated blood glucose and lipid levels, indicating a potential relationship with metabolic issues in diabetes.
- The findings suggest that CF6 may serve as a marker for endothelial dysfunction and could play a role in vascular damage related to diabetes.
Article Abstract
Coupling factor 6 (CF6) is a novel endogenous inhibitor of prostacyclin. Plasma CF6 and 6-keto-PGF(1a) were measured by radioimmunoassay in 70 consecutively recruited patients with type 2 diabetes and in 56 healthy controls. A significantly increased plasma CF6 level was found in diabetics compared with controls. The CF6 level was inversely correlated with plasma 6-keto-PGF(1a) level and positively correlated with blood glucose and lipids. These results suggest that CF6 might be an obvious marker of impaired endothelium and might contribute to vascular damage in diabetes.
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| http://dx.doi.org/10.1016/j.ijcard.2006.05.051 | DOI Listing |
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