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Integrated bioinformatics and interaction analysis to advance chronotherapies for mental disorders.
Front Pharmacol
December 2024
Department of Biotechnology, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India.
Introduction: Robust connections have been identified between the pathophysiology of mental disorders and the functioning of the circadian system. The overarching objective of this study was to investigate the potential for circadian rhythms to be leveraged for therapeutics in mental disorders.
Methods: We considered two approaches to chronotherapy-optimal timing of existing medications ("clocking the drugs") and redressing circadian abnormalities with small molecules ("drugging the clock").
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck.
J Biol Chem
December 2024
Department of Microbiology and Molecular Genetics. Electronic address:
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, combining ATP-site and allosteric kinase inhibitors can overcome these shortcomings in a double-drugging framework. Here we explored the allosteric effects of two pyrimidine diamines, PDA1 and PDA2, on the conformational dynamics and activity of the Src-family tyrosine kinase Hck, a promising drug target for acute myeloid leukemia.
View Article and Find Full Text PDFYearning for Youth and Vitality: A Plastic Surgeon's View of "The House of the Sleeping Beauties" by Yasunari Kawabata.
J Craniofac Surg
December 2024
Department of Plastic Surgery, Armed Forces Capital Hospital, Bundang-gu, Seongnam-City, Gyeonggi-do.
The aim of this study was to analyze "The House of the Sleeping Beauties" (れる) by Yasunari Kawabata from the perspectives of plastic surgery, and psychiatry/psychology. The central theme of the novel focuses on aging, desire, and the human connection to beauty and mortality. The protagonist, Eguchi, frequents a brothel where elderly men lie next to young women who are drugged and remain unconscious.
View Article and Find Full Text PDFAuthor Correction: Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets.
Nat Rev Drug Discov
November 2024
Laboratory of Medical Immunology, Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
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