The hydrolytic activity of Trichomonas vaginalis Donné strains was investigated using API ZYM test (bioMérieux). Among 19 determined hydrolases were found alkaline and acid phosphatases; also in several strains N-acetyl-beta-glucosaminidase and a-glucosidase were demonstrated. The API ZYM test may be used for characterization of enzymatic activity of T. vaginalis strains, but adequate medium is necessary.
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Eur J Pharm Biopharm
January 2025
Centro de Estudos em Biofarmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil. Electronic address:
This scoping review focuses on drug delivery systems based on soft materials designed for the administration of drugs with anti-Trichomonas vaginalis activity. It primarily examines their use in addressing human trichomoniasis, exploring their physicochemical characteristics, in vitro and in vivo evaluation and identifying existing challenges and gaps. Given the economic burden and the One Health approach, formulations developed aiming at treating animal infections - cattle and poultry - were also discussed.
View Article and Find Full Text PDFbioRxiv
January 2025
Laboratorio de Parásitos Anaerobios, Instituto Tecnológico Chascomús (INTECH), CONICET-UNSAM, Buenos Aires, Argentina.
Trichomoniasis, caused by the parasite , is the most common non-viral sexually transmitted infection. Current treatment relies exclusively on 5-nitroimidazole drugs, with metronidazole (MTZ) as the primary option. However, the increasing prevalence of MTZ-resistant strains poses a significant challenge, particularly in the current absence of alternative therapies.
View Article and Find Full Text PDFSex Transm Dis
February 2025
Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Background: Effective strategies to reduce sexually transmitted infection burden and transmission among female sex workers (FSWs) and their networks are needed. We report sexually transmitted infection prevalence among FSWs in Zimbabwe and investigate the performance of screening algorithms.
Methods: Respondent-driven sampling (RDS) surveys, including blood sampling for syphilis serology, were conducted among FSWs in 3 communities in Zimbabwe in 2017.
Iran J Parasitol
January 2024
Parasitology Laboratory, Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, Brazil.
Background: Avian trichomoniasis is an important disease that causes bird mortality, both wild and captive, around the world. This study evaluated the in vitro cytotoxicity, antioxidant, and antiparasitic activity of citral (3.7-Dimetil-2.
View Article and Find Full Text PDFCurr Microbiol
December 2024
B.S.Abdur Rahman Crescent Institute of Science & Technology, Chennai, Tamil Nadu, 600048, India.
Lichen-associated endophytic Actinobacteria, particularly Streptomyces species, are recognized for their production of bioactive secondary metabolites with significant pharmaceutical potential. With the escalating prevalence of diseases, Streptomyces species are being investigated for its natural source of antimicrobial compounds for new antibiotics. This study focuses on the bioactive properties of secondary metabolites from lichen-associated endophytic Actinobacteria, focusing on Streptomyces glaucescens NTSB-37 isolated form lichen, Parmotrema perlatum (Huds.
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