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Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. | LitMetric

Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach.

Reprod Biomed Online

Department of Obstetrics and Gynecology, Cairo University, Misr International Hospital, 40, Abdel Rehim Sabry St, Dokki, Cairo, Egypt.

Published: August 2006

AI Article Synopsis

Article Abstract

In the present study, which includes 287 participants, metformin has been used by women undergoing IVF/intracytoplasmic sperm injection for more than 5 weeks before and during treatment and during luteal phase. There was no significant difference in number of gonadotrophins used, days of stimulation, number of oocytes retrieved, and number of embryos replaced. There was no significant difference in clinical pregnancy rate between both groups but there was significant reduction in the incidence of ovarian hyperstimulation syndrome (OHSS) in the group taking metformin. Metformin is a safe, cheap drug that can help in prevention of OHSS.

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Source
http://dx.doi.org/10.1016/s1472-6483(10)60614-1DOI Listing

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