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Changing Landscape of Randomized Clinical Trials in Stroke: Explaining Contemporary Trial Designs and Methods.
Stroke
November 2024
Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, Oxford University, United Kingdom (L.L.).
Evidence generated from randomized clinical trials (RCTs) plays an indispensable role in advancing clinical stroke care. Although the number of stroke-related RCTs published every year has grown exponentially over the past 25 years, the execution and completion of RCTs, particularly those conducted in a hyperacute setting, have grown more complicated and challenging over the years. In addition to the practical challenges associated with conducting a clinical trial, like obtaining human subjects approval, identifying clinical sites, training trial personnel, and enrolling the target number of patients within the available funding and timeline, the complexity of contemporary RCT designs and analyses has become much more exacting.
View Article and Find Full Text PDFHow can we build veterinary workplaces that are equally welcoming to all, and in which all are supported to excel? That's the question at the heart of this month's Balance. Here Claire Read speaks to a number of vets from minority ethnic backgrounds to discuss possible answers to this vital question.
View Article and Find Full Text PDFEvaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey.
Open Med (Wars)
March 2022
Center for Research in Medical Pharmacology, University of Insubria, 21100, Varese, Italy.
We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long this effect lasted.
View Article and Find Full Text PDFThe prognostic value of the 12-, 6-, 3- and 1-month 'Surprise Question' in cancer patients: A prospective cohort study in three hospitals.
Eur J Cancer Care (Engl)
November 2022
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Objective: This prospective study aimed to evaluate the performance of the 'Surprise Question' (SQ) 'Would I be surprised if this patient died in the next 12 months?' in predicting survival of 12, 6, 3 and 1 month(s), respectively, in hospitalised patients with cancer.
Methods: In three hospitals, physicians were asked to answer SQs for 12/6/3/1 month(s) for inpatients with cancer. Sensitivity, specificity, positive and negative predictive values were calculated.
Dispelling Magnet® Myths.
J Nurs Adm
February 2022
Author Affiliation: Director, Magnet Recognition Program®.
Organizations on the journey to Magnet® excellence have questions. In many cases, those questions are based on myth, not fact. In this month's Magnet Perspectives, we break down the most commonly asked questions, dispel the myths, and explore the resources available to help organizations get the answers they need to achieve Magnet® recognition.
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