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[Infant botulism: an underestimated problem. A review].
Ter Arkh
December 2024
Izhevsk State Medical Academy.
The article is devoted to a form of botulism that has been little studied in our country and is registered exclusively in infants. The fundamental difference between this form and the most common foodborne botulism is that infants become infected by ingestion of spores, followed by their germination, colonization of the intestines and production of botulinum toxin , which leads to the development of life-threatening flaccid paralysis. Taking into account the peculiarities of pathogenesis, the clinical manifestations of infant botulism have some features, which are discussed by the authors.
View Article and Find Full Text PDFFirst case of infant botulism in Sicily-case report.
Ital J Pediatr
November 2024
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.
Article Synopsis
- Botulism is a serious disease caused by a toxin from Clostridium botulinum, leading to muscle paralysis and respiratory issues; diagnosing it can be tough without typical risk factors, such as honey consumption.
- A documented case of infant botulism in Sicily involved an exclusively breastfed baby showing symptoms like poor suction and hypotonia, without any obvious food contamination history.
- The key to the successful treatment was recognizing the signs early, administering botulinum antitoxin, and confirming the diagnosis through tests, emphasizing the need for awareness of all possible exposure sources, including inhalation of contaminated dust.
Iatrogenic botulism after intragastric botulinum neurotoxin injections - a major outbreak.
Neurol Res Pract
October 2024
Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Article Synopsis
- Intragastric botulinum neurotoxin injections (IBNI) are being used as a weight-loss treatment, but an outbreak of severe iatrogenic botulism occurred in early 2023 in Europe after patients received this treatment in Turkey.
- A retrospective analysis was conducted on ten patients in Austria and Germany who experienced severe symptoms like double vision, swallowing difficulties, and paralysis after IBNI.
- Despite the severity of their conditions, all patients were hospitalized, many in intensive care, and ultimately recovered without lasting health issues, underscoring the need for awareness and risk mitigation in medical procedures involving botulinum neurotoxins.
Genomic and phenotypic polymorphism of Clostridium botulinum Group II strain Beluga through laboratory domestication.
Int J Food Microbiol
January 2025
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland. Electronic address:
Article Synopsis
- Laboratory domestication leads to genetic and physiological changes in organisms, impacting foodborne pathogens like Clostridium botulinum.
- Research on C. botulinum Group II Beluga revealed a thymidine dependency due to a mutation in the thyA gene, affecting nutrient synthesis.
- The study emphasizes the importance of monitoring laboratory strains for mutations to ensure accuracy in food safety tests, recommending lower passage numbers and regular genomic checks.
An early scoring system to predict mechanical ventilation for botulism: a single-center-based study.
World J Emerg Med
January 2024
Emergency Department, the Second Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Background: Early identification of patients requiring ventilator support will be beneficial for the outcomes of botulism. The present study aimed to establish a new scoring system to predict mechanical ventilation (MV) for botulism patients.
Methods: A single-center retrospective study was conducted to identify risk factors associated with MV in botulism patients from 2007 to 2022.
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