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A One-Stone-Two-Birds Strategy for Intervertebral Disc Repair: Constructing a Reductive Chelation Hydrogel to Mitigate Oxidative Stress and Promote Disc Matrix Reconstruction.
Adv Mater
December 2024
Key laboratory of Biorheological Science and Technology, Ministry of Educations, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Intervertebral disc degeneration (IVDD) is characterized by fibrosis of nucleus pulposus (NP) cells and accelerated surrounding extracellular matrix catabolism. Bioactive hydrogels have shown significant potential in regulating cellular functions and tissue homeostasis. In this work, a dynamic hydrogel (HA-NCSN/Cu) is designed via the reductive chelation of hyaluronic acid grafted with thiourea (HA-NCSN) and Cu.
View Article and Find Full Text PDFExacerbation of pulmonary fibrosis following acute lung injury via activin-A production by recruited alveolar macrophages.
J Thorac Dis
November 2024
Shanghai Key Laboratory of Lung Inflammation and Injury, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Acute respiratory distress syndrome (ARDS) is a complicated pathological cascade process of excessive pulmonary inflammation and alveolar epithelial cell apoptosis that results in respiratory dysfunction and failure. Some cases of ARDS can result in a more severe state of pulmonary fibrosis, referred to as postinjury lung fibrosis. The mortality and incidence rate of ARDS are high, particularly when it leads to continuing alveolar and interstitial fibrosis, which requires urgent treatment and appropriate management.
View Article and Find Full Text PDFRevisiting the Emerging Role of Light-Based Therapies in the Management of Spinal Cord Injuries.
Mol Neurobiol
December 2024
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India.
The surge in spinal cord injuries (SCI) attracted many neurobiologists to explore the underlying complex pathophysiology and to offer better therapeutic outcomes. The multimodal approaches to therapy in SCI have proven to be effective but to a limited extent. The clinical basics involve invasive procedures and limited therapeutic interventions, and most preclinical studies and formulations are yet to be translated due to numerous factors.
View Article and Find Full Text PDFNew insight into the role of SMAD4 mutation/deficiency in the prognosis and therapeutic resistance of pancreatic ductal adenocarcinomas.
Biochim Biophys Acta Rev Cancer
November 2024
State Key Laboratory of Respiratory Health and Multimorbidity; NHC Key Laboratory of Biotechnology for Microbial Drugs; Department of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, NO. 1 Tiantan Xili, Beijing 100050, China. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC) patients have an unfavorable prognosis and disappointing treatment outcomes because of late diagnosis, high chemotherapy resistance, ineffective adjuvant chemotherapy, unavailable molecular targeted therapy, and profound immunosuppressive effects in the tumor microenvironment (TME). There are a variety of critical driver proteins, such as KRAS, TP53, PTEN and SMAD4, putatively involved in PDAC etiology. Current knowledge of their molecular mechanisms is still limited.
View Article and Find Full Text PDFPrenatal light exposure affects diurnal rhythms and visual development of the layer embryonic retina.
Poult Sci
November 2024
Department of Agricultural Structure and Environmental Engineering, College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Agricultural Engineering in Structure and Environment Ministry of Agriculture and Rural Affairs, Beijing 100083, China; Beijing Engineering Research Center on Animal Healthy Environment, Beijing 100083, China.
It is believed that some wavelengths of light penetrate through eggshell and are perceived by avian embryo, and may consequently affect rhythm establishment and development. This research aimed to explore the influence of prenatal light exposure on the morphological alterations of retinal tissue, the expression of visual developmental signaling systems (TGF-β/Smad pathway), the expression of clock related genes (cClock, cBmal1, cBmal2, cAanat), and melatonin concentration in the chicken embryonic retina. Layer eggs (Jingfen No.
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