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Stem cells exist within a niche, a microenvironment that regulates their activity, but the mechanisms by which niche cells influence stem cell behaviour are poorly understood. In this issue, Stephen DiNardo and colleagues reveal that the shape of the adult Drosophila testes niche, which is dependent on the cytoskeleton of the niche cells, is crucial to maintaining germinal stem cell function. To learn more about this work, we spoke to first author Gabriela Vida and corresponding author Stephen DiNardo, Professor of Cell and Developmental Biology at the University of Pennsylvania, USA.
View Article and Find Full Text PDFDuring early development, embryos coordinate the growth of different tissues to ensure that they reach the correct proportions. A new paper in Development shows that tissue scaling occurs in the tail of the post-gastrulation zebrafish embryo. The study suggests that this scaling is underpinned by multi-tissue tectonics, a mechanism whereby the deformation of one growing tissue can impact the dynamics of a neighbouring tissue.
View Article and Find Full Text PDFEarly sea urchin embryos contain cells called micromeres, which play an important role in the formation of three mesodermal cell types: skeletogenic, blastocoelar and pigment cells. When micromeres are removed, the embryo can replace the skeletogenic and blastocoelar cells via a process called 'transfating', whereby other cells in the embryo step in to take on new roles. However, the pigment cells do not reappear, and the reasons for this are unclear.
View Article and Find Full Text PDFThe interplay between metabolic pathways and the epigenome is essential for proper cell differentiation. In this new study, Francisco Naya and colleagues find that the Dlk1-Dio3 noncoding RNA (ncRNA) locus regulates cell state by coordinating mitochondrial activity and histone modifications in muscle cells. To find out more about the people behind the work, we caught up with first author Amanda Pinheiro and corresponding author Francisco (Frank) Naya, Associate Professor at the Department of Biology, Boston University, USA.
View Article and Find Full Text PDFArriba y Adelante: Looking Outward and Moving Ahead.
Phys Ther
December 2024
Department of and Rehabilitation and Movement Sciences, Rutgers University, Newark, NJ, United States.
Judith E. Deutsch, PT, PhD, FAPTA, the 55th McMillan Lecturer, is professor and director of the Research in Virtual Environments and Rehabilitation Sciences (Rivers) Lab in the Doctoral Programs in Physical Therapy in the School of Health Professions at Rutgers University. Her current research includes the development and testing of virtual reality, serious games to improve mobility and fitness of individuals with neurologic health conditions, and knowledge translation to strengthen evidence-based practice.
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