AI Article Synopsis
- The study examined 1,449 patients with chronic lymphocytic leukemia (CLL) to assess how family history affects prognosis.
- A family history of hematologic malignancies was found in 12.5% of cases, with higher occurrences in females, and 6% of patients had relatives also affected by CLL.
- Despite the familial ties, both familial and sporadic cases showed similar rates of advanced stages, treatment needs, and 10-year survival probabilities, indicating that a family history does not worsen CLL prognosis.
Article Abstract
The prognostic impact of the presence of a familial trait was analyzed in 1449 patient with chronic lymphocytic leukemia (CLL). A family history of hematologic malignancy (HM) was identified in 181 cases (12.5%) and recorded more frequently among female than male patients (HM: p < 0.05; CLL: p < 0.05). The relative was affected by CLL in 89 cases (6%). Familial and sporadic cases showed non-statistically different proportions of advanced stages (10.8 vs 7.1%) and patients requiring therapy (55 vs 60%) and a similar survival probability at 10 years (67 vs 66%). These data suggest that in CLL the presence of a familial trait does not imply an adverse prognosis.
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