AI Article Synopsis
- * Microinjecting AVP into the CdN increases pain thresholds in a dose-dependent way, while blocking its receptors lowers pain thresholds.
- * Results suggest that AVP levels in the CdN are crucial for pain regulation, as its effects can be reversed by specific receptor antagonists.
Article Abstract
Our previous work has shown that arginine vasopressin (AVP) regulates antinociception through brain nuclei rather than the spinal cord and peripheral organs. The present study investigated the nociceptive effect of AVP in the caudate nucleus (CdN) of the rat. Microinjection of AVP into the CdN increased pain threshold in a dose-dependent manner, while local administration of AVP-receptor antagonist-d(CH(2))(5)Tyr(Et)DAVP decreased pain threshold. Pain stimulation elevated AVP concentration in CdN perfuse liquid. CdN pretreatment with AVP-receptor antagonist completely reversed AVP's effect on pain threshold in the CdN. The data suggest that AVP in the CdN is involved in antinociception.
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| http://dx.doi.org/10.1016/j.lfs.2006.07.005 | DOI Listing |
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