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Potential anti-schistosomal effect of Daflon, a repurposed drug targeting different stages of Schistosome maturity.
Parasitol Res
November 2024
Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Despite the long history of experimental trials to combat schistosomiasis, it remains a significant burden due to drug resistance and the effectiveness of the standard treatment only against the mature stage, while skipping other early developmental stages thus leading to severe permanent pathological sequelae. Therefore, repurposing a commonly used well-known safe drug would be a wise alternative. We investigated the potential anti-schistosomal drug activity of Daflon® (DAF) against different schistosomal developmental stages.
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Ugeskr Laeger
May 2024
Patologisk Afdeling, Københavns Universitetshospital - Herlev og Gentofte Hospital.
Epididymal bilharzia simulating a testicular tumor: A case report.
IDCases
April 2023
Department of Anatomy and Pathological Cytology CHU, Tengandogo, Ouagadougou, Burkina Faso.
Bilharzia or schistosomiasis is a parasitic disease due to infestation by a hematophagous trematode of the genus Schistosoma. It is the second most frequent parasitic endemic in the world after malaria. The most frequent tissue infections are intestinal and genitourinary.
View Article and Find Full Text PDFBlood Flukes and Arterial Damage: A Review of Aneurysm Cases in Patients with Schistosomiasis.
Can J Infect Dis Med Microbiol
December 2022
Department of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, P.O. Box 65011, Dar es Salaam, Tanzania.
Introduction: Schistosomiasis, caused by trematode worms of the genus , has organ-specific morbidity due to host's inflammatory response to the oviposition of parasite eggs in vessels and organs. Damage to the cardiovascular system, including aneurysms, has been described in patients. .
View Article and Find Full Text PDFTesticular schistosomiasis: a systematic review of the literature.
Can J Urol
December 2022
Department of Urology, New York University Grossman School of Medicine, New York, New York, USA.
Introduction: To consolidate reported information on presentation, diagnosis, and treatment modalities in testicular schistosomiasis (TS) to provide a reference tool for this rare disease.
Materials And Methods: A comprehensive PubMed search was performed using PRISMA guidelines, which yielded 21 articles detailing 22 cases of TS.
Results: Testicular schistosomiasis remains a rare disease, presenting at a variety of ages (median age 27).
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