AI Article Synopsis
- The glutamine transport system in tumor cells is enhanced to support their rapid growth, requiring significant glutamine intake.
- Gd-DOTAMA-C6-Gln, a specialized MRI reporter linked with glutamine, has been shown to accumulate in tumor cells, as evidenced by both laboratory and live experiments.
- Intravenous delivery of Gd-DOTAMA-C6-Gln successfully allowed MRI visualization of tumors in mouse models of neuroblastoma and breast cancer.
Article Abstract
The glutamine transporting system is up-regulated in tumor cells because cell proliferation requires the uptake of large quantities of glutamine. It has been found that the paramagnetic magnetic resonance imaging (MRI) reporter Gd-DOTAMA-C6-Gln, where the glutamine residue is covalently bound to the Gd chelate through a C6 spacer, accumulates in tumor cells both "in vitro" and "in vivo" experiments. The observation that the relaxivity of cellular pellets does not increase with the increase in the amounts of entrapped Gd chelate is taken as an indication that the internalization has occurred through receptor mediated endocytosis. The iv administration of Gd-DOTAMA-C6-Gln allowed the MRI visualization of tumor masses in A/J mice grafted with the murine neuroblastoma cell line Neuro-2a and in Her-2/neu transgenic mice developing multiple mammary carcinoma, respectively.
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| http://dx.doi.org/10.1021/jm0601093 | DOI Listing |
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