AI Article Synopsis
- Nitric oxide (NO) is a gas produced from arginine by the enzyme nitric oxide synthetase (NOS), playing various biological roles.
- Loss of retinal ganglion cells is a key feature of several eye diseases, such as glaucoma and optic neuritis, which may involve NO in their pathology.
- NO is implicated in regulating intraocular pressure, managing ocular blood flow, and influencing cell death (apoptosis) in the context of ocular diseases.
Article Abstract
Nitric oxide (NO) is a gas with diverse biological activities produced from arginine by nitric oxide synthetase (NOS). The loss of retinal ganglion cells is a hallmark of many ophthalmic diseases including glaucoma, retinal ischemia due to central artery occlusion and anterior ischemic optic neuropathy. It may well be significant in optic neuritis, optic nerve, trauma and AIDS. NO appears to be involved in the regulation of intraocular pressure, in the modulation of ocular blood flow and in apoptosis. This article gives a short and simplified overview of the biochemistry of NO and its role in physiology and pathogenesis of ocular diseases.
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