The use of a new chiral lanthanide complex derived from a europium dithiocarbamate complex and a N-tosylated amino acid for the asymmetric synthesis of cyanohydrins is described. In some cases, high enantioselectivities were observed.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/b607741m | DOI Listing |
J Org Chem
January 2025
Jiangxi Province Key Laboratory of Functional Organic Polymers, East China University of Technology, Nanchang 330013, China.
This study proposes a green and efficient atom- and step-economical method for converting hazardous CS to dithiocarbamate derivatives under visible light irradiation and catalyst-free conditions. By the construction of novel C-S and C-N bonds, a series of β-dicarbonyl compounds and amines are incorporated into the products. Under light, CS and amine first form bis(dialkylaminethiocarbonyl)disulfides, which then react with KCO-activated β-dicarbonyl compounds to form electron donor-acceptor (EDA) complexes and subsequently generate the target products.
View Article and Find Full Text PDFDalton Trans
January 2025
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, India.
Electrochemical water oxidation holds immense potential for sustainable energy generation, splitting water into clean-burning hydrogen and life-giving oxygen. However, a key roadblock lies in the sluggish nature of the oxygen evolution reaction (OER). Finding stable, cost-effective, and environmentally friendly catalysts with high OER efficiency is crucial to unlock this technology's full potential.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Inorganic Chemistry, Shahid Beheshti University, Tehran, 19839 69411, Iran.
Five metal dithiocarbamate complexes [M(PTHIQDTC)] [where PTHIQDTC is (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline dithiocarbamate anion and M is Ni(II) (1), Sn(II) (2), Hg(II) (3), Pb(II) (4) and Zn(II) (5)] were synthesized from the reaction of MX (X is Cl for 1-3 and OAc for 4-5) with ligand of triethylammonium (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline dithiocarbamate [EtNH][PTHIQDTC] in methanolic solution at room temperature. The five complexes were characterized by IR, H andC NMR, mass spectrometry, elemental analysis and TGA analysis. Recrystallization of [Zn(PTHIQDTC)] (5) in dimethylsulfoxide (DMSO) converts 5 to [Zn(PTHIQDTC)(DMSO)] (6).
View Article and Find Full Text PDFAnalyst
November 2024
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Pesticides are primarily used in agriculture to protect crops and extend their longevity. However, pesticide exposure has been linked to various acute and chronic health effects, raising significant environmental concerns. Current detection methods are often expensive and time-consuming, relying on complex instruments.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Department of Chemistry, University of Kentucky, Lexington, Kentucky, United States; Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA; Center for Bioelectronics and Nanomedicine, University of Kentucky, Lexington, Kentucky, USA. Electronic address:
The elusiveness of triple-negative breast cancer from targeted therapy has redirected focus toward exploiting the metabolic shortcomings of these highly metastatic subtypes of breast cancer. Cueing from the metabolic heterogeneity of TNBC and the exposition of the dual dependence of some TNBCs on OXPHOS and glycolysis for ATP, we herein report the efficacy of cotreatment of TNBCs with an OXPHOS inhibitor, 2a and 2DG, a potent glycolysis inhibitor. 2a-2DG cotreatment inhibited TNBC cell proliferation with IC of ∼5 to 36 times lower than that of 2a alone and over 5000 times lower than IC of 2DG alone.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!