AI Article Synopsis
- The hypoxic response in humans is controlled by a process called post-translational hydroxylation of a protein known as hypoxia inducible transcription factor (HIF).
- Researchers studied a recombinant version of a human enzyme called prolyl-4-hydroxylase (PHD2) and found it has a surprisingly strong attraction for its iron cofactor and 2-oxoglutarate, a key molecule involved in its activity.
- This interaction indicates that PHD2 may play a significant role in regulating how cells respond to low oxygen levels in the body.
Article Abstract
Regulation of the hypoxic response in humans is regulated by the post-translational hydroxylation of hypoxia inducible transcription factor; a recombinant form of a human prolyl-4-hydroxylase (PHD2) was characterised and shown to have an unexpectedly high affinity for, and to copurify with endogenous levels of, its Fe(ii) cofactor and 2-oxoglutarate cosubstrate.
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| http://dx.doi.org/10.1039/b511249b | DOI Listing |
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