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The role of leptin in innate and adaptive immune responses. | LitMetric

The role of leptin in innate and adaptive immune responses.

Arthritis Res Ther

Department of Experimental Research, Institute of Experimental and Clinical Medicine, Vilnius University, Vilnius, Lithuania.

Published: February 2007

Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438PMC
http://dx.doi.org/10.1186/ar2004DOI Listing

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