Objective: To determine whether the addition of low-cost reflecting curtains to a standard phototherapy unit could increase effectiveness of phototherapy for neonatal jaundice.
Design: Randomised controlled clinical trial.
Setting: Level-one nursery of the Hospital Universiti Sains Malaysia, Kelantan, Malayasia.
Patients: Term newborns with uncomplicated neonatal jaundice presenting in the first week of life.
Interventions: Phototherapy with white curtains hanging from the sides of the phototherapy unit (study group, n = 50) was compared with single phototherapy without curtains (control group, n = 47).
Main Outcome Measures: The primary outcome was the mean difference in total serum bilirubin measured at baseline and after 4 h of phototherapy. The secondary outcome was the duration of phototherapy.
Results: The mean (standard deviation) decrease in total serum bilirubin levels after 4 h of phototherapy was significantly (p<0.001) higher in the study group (27.62 (25.24) micromol/l) than in the control group (4.04 (24.27) micromol/l). Cox proportional hazards regression analysis indicated that the median duration of phototherapy was significantly shorter in the study group (12 h) than in the control group (34 h; chi(2) change 45.2; p<0.001; hazards ratio 0.20; 95% confidence interval 0.12 to 0.32). No difference in adverse events was noted in terms of hyperthermia or hypothermia, weight loss, rash, loose stools or feeding intolerance.
Conclusion: Hanging white curtains around phototherapy units significantly increases efficacy of phototherapy in the treatment of neonatal jaundice without evidence of increased adverse effects.
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http://dx.doi.org/10.1136/adc.2006.095687 | DOI Listing |
Neonatal jaundice is a common condition affecting four out of five healthy newborns, characterized by the yellowing of the skin due to elevated bilirubin levels. This condition, known as hyperbilirubinemia, is typically benign and transient when properly managed but may progress to severe complications such as kernicterus-a permanent neurologic condition-if untreated. Newborns are particularly susceptible to jaundice due to increased red blood cell turnover, immature liver enzymes, and delayed stooling patterns.
View Article and Find Full Text PDFBMC Pediatr
March 2025
Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur (UniKL-RCMP), Ipoh, Malaysia.
Background: In the Malaysian primary healthcare setting, neonatal jaundice (NNJ) screening uses either Kramer's Rule (KR), a visual assessment, or a combination with non-invasive transcutaneous bilirubin (TcB). However, data on the quantification of the need for total serum bilirubin (TSB) sampling between these approaches are limited. This study aimed to compare the frequency of blood draws required between the two cohorts, alongside investigating disparities in phototherapy initiation and severe hyperbilirubinemia occurrences.
View Article and Find Full Text PDFMidwifery
February 2025
Department of Neonatal and Paediatric Intensive Care, Division of Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Medical Centre Rotterdam, Rotterdam, the Netherlands; Department of Internal Medicine, Division of Nursing Science, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Background: Phototherapy for hyperbilirubinaemia in neonates is one of the most frequent causes of hospitalisation in the first week of life, accounting for up to 35 % of hospital (re)admissions. Studies suggest that phototherapy can be applied safely and effectively at home. However, in-hospital phototherapy is still the standard care in most settings.
View Article and Find Full Text PDFAJOG Glob Rep
February 2025
College of Medicine, University of Cincinnati, Cincinnati, OH (Markham).
Background: Clinical manifestations of hemolytic disease of the fetus and newborn include anemia, hyperbilirubinemia, hydrops fetalis, kernicterus, and fetal or neonatal demise. More than 50 antibodies are linked to hemolytic disease of the fetus and newborn, with Rhesus (including D and c) and Kell antigens carrying the highest risk of disease. To date, a multicenter, comprehensive evaluation of hemolytic disease of the fetus and newborn due to Rhesus antigen alloantibodies in the United States has not been undertaken.
View Article and Find Full Text PDFBrain Dev
February 2025
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Objectives: Bilirubin encephalopathy in preterm infants (pBE) is becoming a growing concern in Japanese neonatal intensive care units. Definitive conclusions regarding the risk factors of pBE remain elusive. This study aimed to identify the risk factors for pBE.
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