Purpose: To report an uncommon case of multifocal choroiditis as the result of disseminated Cryptococcus neoformans infection in a patient who is HIV-positive.
Design: Interventional case report.
Methods: A 27-year-old HIV-positive woman with fever, headache, and vomiting was examined. Lumbar puncture was performed and revealed C neoformans infection. Her condition evolved with sudden bilateral blindness and deafness. Ophthalmologic examination revealed multiple yellowish choroidal lesions in the posterior pole of both eyes.
Results: Postmortem examination showed disseminated C neoformans infection. Histologic examination of the eyes confirmed the presence of C neoformans in the choroiditis.
Conclusion: Multifocal choroiditis in C neoformans infection is a rare ophthalmic manifestation. The recognition of this condition by ophthalmologists can help physicians to diagnose a disseminated and fatal disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajo.2006.03.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
11C-Methionine PET/CT in Cryptococcus Meningoencephalitis.
Clin Nucl Med
February 2025
From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.
A 70-year-old man experienced an epileptic seizure. Subsequent MRI performed on close examination revealed high signal in the left occipital cortex on fluid-attenuated inversion recovery. Gadolinium contrast indicated enhancement along the cortex.
View Article and Find Full Text PDFCryptococcal meningoencephalitis in a patient on immunomodulatory drug: A case report.
J Mycol Med
December 2024
Fimlab Laboratories, 33520 Tampere, Finland / Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland; Northern Finland Laboratory Centre (NordLab), 90220 Oulu / Finland and Research Unit of Biomedicine, University of Oulu, 90570 Oulu, Finland.
Background: Cryptococcus neoformans is an important fungal pathogen causing pneumonia and central nervous system infections mainly in immunocompromised hosts. Fingolimod is an immunomodulatory drug approved in the US and Europe for the treatment of multiple sclerosis.
Case Presentation: We herein report a case of cryptococcal meningoencephalitis in a 46-year-old male with a history of fingolimod for five years.
Synthesis and characterization of innovative GA@Ag-CuO nanocomposite with potent antimicrobial and anticancer properties.
Sci Rep
January 2025
Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Badr University in Cairo (BUC), Badr city, Cairo, Egypt.
Cancer and microbial infections place a significant burden on the world's health systems and can increase the rate of disease and mortality. In the current study, a novel nanocomposite based on Gum Arabic, silver and copper oxide nanoparticles (GA@Ag-CuO nanocomposite) was synthesized to overcome the problem of microbial infection and in cancer treatment. Characterization using UV-Vis.
View Article and Find Full Text PDFMinimal domain peptides derived from enterocins exhibit potent antifungal activity.
Front Fungal Biol
December 2024
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.
The antimicrobial peptide (AMP) circularized bacteriocin enterocin AS-48 produced by sp. exhibits broad-spectrum antibacterial activity via dimer insertion into the plasma membrane to form membrane pore structures, compromising membrane integrity and leading to bactericidal activity. A specific alpha-helical region of enterocin AS-48 has been shown to be responsible for the membrane-penetrating activity of the peptide.
View Article and Find Full Text PDFDivergent paths: gene evolution in Cryptococcus and implications for pathogenicity.
Curr Med Mycol
April 2024
Department of Biotechnology, College of Science, University of Anbar, Ramadi, Anbar, Iraq.
Background And Purpose: and are highly virulent species that cause diseases, such as meningoencephalitis and pulmonary infections. The gene predominantly determines the virulence of the pathogenic species. This study aimed to examine in both pathogenic and non-pathogenic species.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!