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Cryoblebbing with 5-fluorouracil versus cryoblebbing with melanocyte keratinocyte transplant procedure or cryoblebbing alone in treatment of stable vitiligo.
Arch Dermatol Res
January 2025
Dermatology and Venereology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Both the surgical non-cultured melanocyte-keratinocyte transplant procedure (MKTP) and intradermal injection of 5-Fluorouracil (5-FU) are effective in the treatment of vitiligo. Intrablisters injection of MKTP was done in one study with better results than MKTP application after ablative CO2 laser of the reciepient area. However, intrablister injection of 5-FU was not done before.
View Article and Find Full Text PDFMicroneedling and 5-Fluorouracil in Treating Stable Vitiligo in Hitherto Unstudied High Prevalence Population.
Indian J Dermatol
October 2024
From the Department of Dermatology, Venereology, Leprosy - Mahatma Gandhi Memorial Medical College and Hospital, Jamshedpur and Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Article Synopsis
- Vitiligo is a skin condition that affects about 0.25% of the Indian population, with higher prevalence in certain areas, leading to significant psychological issues such as depression due to social stigma.* -
- An interventional study analyzed the effects of microneedling combined with 5% 5-fluorouracil treatment on stable vitiligo patches, involving 30 participants over 12 sessions from 2019 to 2021.* -
- Results showed that 56% of participants achieved excellent or very good repigmentation, averaging a 54% improvement after about 4 months of treatment, with manageable side effects.*
Potential execution of vitiligo surgery by the most conceivable technique - which, where, and why?
J Cutan Aesthet Surg
October 2024
Department of Dermatology, The Humanitarian Clinic: Skin, Hair and Laser Centre, Mumbai, Maharashtra, India.
While various treatment options exist for vitiligo, surgical interventions have gained significant attention due to their potential for long-lasting repigmentation. Several surgical procedures have been developed, including miniature punch grafting, thin Theirsch's split-thickness skin grafting (STSG), suction blister technique, and ultrathin STSG. The decision-making process should also consider the potential risks and benefits associated with each technique.
View Article and Find Full Text PDFJAK inhibitors in immune regulation and treatment of vitiligo.
Cytokine Growth Factor Rev
December 2024
Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Dermatology, The First Hospital of China Medical University, Shenyang, China. Electronic address:
Article Synopsis
- - Vitiligo is a skin disorder characterized by loss of pigmentation, affecting both the appearance and mental well-being of those affected, as it involves a decrease in functioning melanocytes which produce skin color.
- - Treatment options for vitiligo include glucocorticoids, immunosuppressants, phototherapy, and surgical methods, but recent studies highlight the role of Janus kinase (JAK) hyperactivation and pro-inflammatory cytokines in escalating the condition by harming melanocytes.
- - New research shows that JAK inhibitors can effectively counteract the negative effects of these signaling pathways, leading to potential repigmentation of the skin, and this review discusses their mechanisms and applications for improving vitiligo treatments.
Effective and durable repigmentation for stable vitiligo: A randomized within-subject controlled trial assessing treatment with autologous skin cell suspension transplantation.
J Am Acad Dermatol
December 2024
Palo Alto Foundation Medical Group, Sunnyvale, California.
Article Synopsis
- - The study developed a new device for preparing autologous skin cell suspension (ASCS) containing melanocytes to treat stable vitiligo, which is often difficult to repigment using conventional methods.
- - In a trial involving 25 subjects, the ASCS treatment showed significant effectiveness, with 36% of lesions achieving at least 80% repigmentation after 24 weeks, compared to none in the control group.
- - The results suggest that ASCS could be a promising treatment for stable vitiligo, potentially enhancing patients' quality of life, although the small sample size limits deeper analysis.
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