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Could CGRP mAbs for migraine trigger rheumatoid arthritis? Insights from a case report.
ARP Rheumatol
January 2025
ULS Gaia e Espinho.
Background: Case reports suggest that calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) may trigger inflammatory flares in patients with autoimmune diseases.
Case Description: A 56-year-old woman with a history of severe migraines, experienced improvement in migraine frequency and intensity after starting fremanezumab 225 mg monthly. However, three months into treatment, she developed symmetric inflammatory polyarthralgias.
Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study.
PeerJ
December 2024
Department of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Objective: To characterize the epidemiological characteristics of malignancy in Chinese patients with rheumatoid arthritis (RA) American patients and investigate their associated factors.
Methods: Data were collected from a real-world Chinese RA population and American patients with RA from the National Health and Nutritional Examination Survey. The prevalence and subtypes of malignancy and their potential associated factors were investigated in both populations.
Rheumatoid Arthritis and Heart Failure: A Narrative Review.
Cureus
November 2024
Medicine, Apollo Hospitals, Anantapur, IND.
Rheumatoid arthritis (RA) is a chronic inflammatory process involving the joints and the cartilage. Early diagnosis and treatment of RA are crucial to prevent further complications like heart failure (HF), cervical subluxation, membranous glomerulonephritis, and parenchymal lung disease. HF is the leading cause of death in various chronic illnesses.
View Article and Find Full Text PDFQuantitative real-time PCR analysis of gut microbiota in rheumatoid arthritis patients compared to healthy controls.
AMB Express
December 2024
Department of Medical Microbiology and Immunology, Faculty of Medicine, Shahrekord Medical University, Shahrekord, Iran.
Rheumatoid arthritis (RA) is an autoimmune disorder with synovial inflammation of joints and extra articular manifestations. The results of recent researches consider the relationship between microbiota and the immune system as a double-edged sword. Considering that the relationship between the composition of intestinal microbiota and the immunological and clinical status of the body has been confirmed, it is very important to investigate the effect of each genus and species of bacteria on the state of the immune system.
View Article and Find Full Text PDFNatural killer cell activity and its relationship with disease activity in rheumatoid arthritis patients.
Hum Immunol
December 2024
Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. Electronic address:
Article Synopsis
- The study investigated how natural killer cell activity (NKA) relates to the severity of rheumatoid arthritis (RA) by analyzing data from 259 patients.
- Patients were split into low NKA (< 100 pg/mL) and high NKA (100-250 pg/mL) groups, with the low NKA group showing more severe RA symptoms and higher usage of TNF-α antagonists.
- Results indicated a negative correlation between NKA levels and various measures of RA severity, suggesting that lower NKA is associated with worse disease characteristics and increased inflammation.
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