AI Article Synopsis
- Some scientists think that a process called autophagy, which usually helps cells clean up and recycle, can also cause cells to die, but this idea is debated.
- Some believe that autophagic cell death is just a strange type of another process called apoptosis, which is a more common way for cells to die.
- However, new research suggests that autophagy can actually cause even healthy cells that can usually go through apoptosis to die too.
Article Abstract
Despite abundant evidence for autophagic cell death as a morphological type, the notion that autophagy can actually contribute mechanistically to the cell's death is controversial. In cells capable of apoptosis, autophagic cell death has been dismissed by some authors as a morphologically unusual form of apoptosis. But strong recent evidence for autophagy-mediated death of cells rendered incapable of apoptosis has been criticized on the grounds that this cell death is too artificial to be relevant to normal cells. We here argue from our own and other recent evidence that autophagy can mediate the death even of apoptosis-competent cells.
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| http://dx.doi.org/10.4161/auto.2.2.2443 | DOI Listing |
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