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Evaluating Avacopan in the Treatment of ANCA-Associated Vasculitis: Design, Development and Positioning of Therapy.
Drug Des Devel Ther
January 2025
Center of Expertise for Lupus-, Vasculitis- and Complement-Mediated Systemic Diseases (Luvacs), Department of Internal Medicine - Nephrology Section, Leiden University Medical Center, Leiden, the Netherlands.
Recently, avacopan has been approved for the treatment of ANCA-associated vasculitis (AAV). Avacopan is an inhibitor of the C5a-receptor, which plays an important role in chemotaxis and the amplification loop of inflammation in AAV. In the most recent, international guidelines avacopan is recommended as steroid-sparing agents for the management of AAV.
View Article and Find Full Text PDFHow We Treat ANCA-Associated Vasculitis: A Focus on the Maintenance Therapy.
J Clin Med
January 2025
University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnet and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital, ASL Città di Torino and University of Torino, 10154 Turin, Italy.
Recent progress has notably improved outcomes for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), namely granulomatosis with polyangiitis and microscopic polyangiitis. Since 2021, several international scientific societies have recommended rituximab (RTX) as the preferred primary treatment for maintaining remission in AAV patients. Decisions regarding retreatment with RTX are based on individual patient risk factors for disease flare-ups and the potential consequences of such flares.
View Article and Find Full Text PDFRare Clinical Manifestation of Vasculitis.
Diagnostics (Basel)
November 2024
Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Article Synopsis
- ANCA-associated vasculitis is linked to a significantly higher risk of cardiovascular issues, with rare but serious coronary artery involvement.
- A 68-year-old woman with p-ANCA vasculitis and severe kidney disease presented with chest pain and low blood pressure, showing signs of coronary vasospasm rather than blockage during testing.
- Treatment with medications such as amlodipine and corticosteroids successfully resolved her symptoms, highlighting the immune-mediated nature of the vascular inflammation.
Relationships between patient and physician global assessments in anti-neutrophil cytoplasmic antibody-associated vasculitis.
Clin Rheumatol
January 2025
Department of Nephrology, Monash Medical Centre, Monash Health, Clayton, Victoria, Australia.
Introduction/objectives: Patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) experience reduced health-related quality of life (HRQoL). Global assessment tools use visual analogue scales to provide patients' and physicians' views on disease activity or the patient's overall health and well-being. The aim of this study was to examine the relationships between patient and physician global assessments (PtGA and PhGa) as they relate to overall health in people with AAV.
View Article and Find Full Text PDFInsights from Portuguese Nephrologists and Rheumatologists Concerning the Treatment of ANCA Vasculitis.
Acta Med Port
November 2024
Article Synopsis
- AAV includes several serious diseases that cause inflammation and damage to blood vessels, leading to various health complications.
- An online Delphi panel with 55 Portuguese specialists aimed to determine the consensus on AAV treatment and adherence to European guidelines but found no global consensus on treatment statements.
- The findings indicate partial alignment with European recommendations but emphasize the need for standardized treatment practices for AAV in Portugal.
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