The wound healing process is a highly orchestrated process, which includes inflammation, re-epithelialization, granulation tissue formation, matrix formation and re-modeling. In this paper, we attempt to determine if bio-active ceramic resource powder particles had an effect on cutaneous wound healing. Furthermore, we investigated its related mechanism and the expression of Smads of cutaneous wound healing, which can be accelerated by bio-active ceramic ointment. Topically applied lesions of 5%, 10% and 15% bio-active ceramic ointment (AO) showed accelerated wound closure, re-epithelialization, and the related immediate down stream of TGF-beta (p-Smad2/3 and Smad3) was suppressed. In particular, 10% and 15% AO lesions became closed faster at Days 3 and 4 of post-wound and p-Smad2/3 was also suppressed. All AO lesions showed accelerated mild wound closure at Day 6, but there were no significant difference. Several papers reported that Smad3 may mediate the signaling pathways that is inhibitory to wound healing, as the deletion of Smad3 leads to enhanced re-epithelialization and contraction of the wound area. This study showed that topical, bio-active ceramic ointment applications accelerated wound closure, re-epithelialization and the suppression of Smad proteins (p-Smad2/3, Smad3). The data revealed that the suppression of Smad3, which was induced by bio-active ceramic resources powder particles affected re-epithelialization and cutaneous wound closure. At the end of this paper, we concluded that bio-active ceramic resources affect cutaneous wound healing by accelerating the re-epithelialization of keratinocytes and that is mediated by the suppression of related protein, Smad3.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11010-006-9283-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Case-control Study: Comparative Evaluation of Bio active Glass (Novabone Putty) and Demineralized Freeze-dried Bone Allograft in the Treatment of Mandibular Furcation Defects.
J Contemp Dent Pract
July 2024
Department of Orthodontics, Malla Reddy Institute of Dental Studies, Hyderabad, Telangana, India, ORCID: https://orcid.org/0000-0002-7301-4628.
Aim: The aim of this study was to compare a second-generation bioactive glass putty biomaterial (Novabone putty) against demineralized freeze-dried bone allograft (DFDBA) in mandibular grade II furcation defects.
Materials And Methods: Fifteen systematically healthy individuals in the age range of 38-50 years were selected for this split-mouth study. Group I consisting of 15 sites, was treated with DFDBA and group II consisting of 15 sites was treated with Novabone putty (NB putty).
Anion Exchange Facilitates the In Situ Construction of Bi/BiO Interfaces for Enhanced Electrochemical CO -to-Formate Conversion Over a Wide Potential Window.
Small
October 2023
State Key Laboratory of Materials-Oriented Chemical Engineering, and School of Energy Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Electrochemical reduction of CO (CO RR) into value-added products is a promising strategy to reduce energy consumption and solve environmental issues. Formic acid/formate is one of the high-value, easy-to-collect, and economically viable products. Herein, the reconstructed Bi O CO nanosheets (BOC NSs) are synthesized by an in situ electrochemical anion exchange strategy from Bi O SO as a pre-catalyst.
View Article and Find Full Text PDFOsteogenic differentiation of adipose-derived canine mesenchymal stem cells seeded in porous calcium-phosphate scaffolds.
Front Vet Sci
June 2023
Bone Regeneration Research Group, Department of Animal Medicine and Surgery, Veterinary Faculty, Autonomous University of Barcelona, Cerdanyola del Vallès, Spain.
Introduction: Engineered bone graft substitutes are a promising alternative and supplement to autologous bone grafts as treatments for bone healing impairment. Advances in human medicine extend an invitation to pursue these biomimetic strategies in animal patients, substantiated by the theory that specialized scaffolds, multipotent cells, and biological cues may be combined into a bioactive implant intended for the enhancement of tissue regeneration.
Methods: This proof-of-concept study was designed to evaluate and validate the feasibility of beta-tricalcium phosphate foam scaffolds seeded with canine mesenchymal stem cells derived from adipose tissue.
Electrochemical and In Vitro Biological Evaluation of Bio-Active Coatings Deposited by Magnetron Sputtering onto Biocompatible Mg-0.8Ca Alloy.
Materials (Basel)
April 2022
Department of Orthopedics and Traumatology, University of Medicine and Pharmacy Gr.T.Popa Iasi, 16 University Str., 700115 Iasi, Romania.
The use of resorbable magnesium alloys in the design of implants represents a new direction in the healthcare domain. Two main research avenues are currently explored for developing or improving metallic biomaterials: (i) increase of their corrosion resistance by designed compositional and structural modifications, and (ii) functionalization of their surfaces by coating with ceramic or polymeric layers. The main objective of this work was to comparatively assess bio-functional coatings (i.
View Article and Find Full Text PDFInvestigating the mechanical, physiochemical and osteogenic properties in gelatin-chitosan-bioactive nanoceramic composite scaffolds for bone tissue regeneration: In vitro and in vivo.
Mater Sci Eng C Mater Biol Appl
January 2019
Department of Veterinary Surgery and Radiology, WBUAFS, Kolkata, India. Electronic address:
The aim of this work was to compare the efficacy of gelatin-chitosan based bone scaffolds after incorporation of three different bioactive nanoparticles such as hydroxyapatite (HAp), β‑tricalcium phosphate (β-TCP) and 58s bio active glass by evaluating its physicochemical, mechanical and osteogenic properties. Gelatin-chitosan based scaffolds made of gelatin-chitosan (GC) and GC composites containing 30 wt% HAp, β-TCP and 58s bioactive glass nanoparticles were fabricated using freeze drying technique. The porosity and compressive strength of all the prepared scaffolds were evaluated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!