AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indicated that AG205 exerts antibacterial activity against S. pneumoniae through the specific inhibition of FabK.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538662 | PMC |
| http://dx.doi.org/10.1128/AAC.00270-06 | DOI Listing |
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