A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 microM) and demonstrated modest adhesion inhibition to cell surface CSA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538674 | PMC |
| http://dx.doi.org/10.1128/AAC.00313-06 | DOI Listing |
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