AI Article Synopsis
- A new series of inhibitors for human soluble epoxide hydrolase (sEH) has been created, showing varying effectiveness.
- The compounds demonstrate inhibition potency between 4.2 microM to 1.1 nM against the enzyme.
- One specific inhibitor, N-(1-Acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea (5a), was notably potent (IC(50) = 7.0 nM) and can be taken orally in dogs.
Article Abstract
A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 microM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea (5a) was found to be a potent inhibitor (IC(50) = 7.0 nM) that was also orally bioavailable in canines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904344 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2006.07.009 | DOI Listing |
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