AI Article Synopsis
- The study examined the levels of nitrate and nitrite, as well as antioxidant activity in leukocytes from gastric cancer patients, and assessed their relationship with tumor grade.
- Leukocyte nitrate and nitrite levels were found to be higher in patients with gastric cancer, especially those with high-grade tumors, while superoxide dismutase activity was lower compared to healthy controls.
- The findings suggest that elevated levels of leukocyte nitrate and nitrite correlate with more advanced tumor grades, but antioxidant activity impairment appears unrelated to tumor grade.
Article Abstract
In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. Leukocyte nitrate and nitrite level was found to be increased and superoxide dismutase activity was found to be decreased in patients compared to controls. When the patient group was categorized, nitrate and nitrite level was found to be higher in patients with a high-grade tumor than in patients with a grade I tumor. We concluded that an increased level of leukocyte nitrate and nitrite is related to tumor grade in patients with gastric cancer; antioxidant activity is also impaired in these patients but it does not seem to be related to grade of tumor.
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| http://dx.doi.org/10.1007/s10620-005-9021-0 | DOI Listing |
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