Mitochondria are dynamic organelles, essential for cell life and death. The morphology of this organelle is determined by fusion and fission, controlled by a growing set of "mitochondria-shaping" proteins, which influence crucial signalling cascades, including apoptosis.
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Evidence of the association between the Q2 mitochondrial group of Bemisia tabaci MED species (Hemiptera: Aleyrodidae) and low competitive displacement capability.
PLoS One
January 2023
Entomology and Nematology Department, Gulf Coast Research and Education Center, University of Florida, Wimauma, FL, United States of America.
The whitefly, Bemisia tabaci (Gennadius), is one of the most serious agricultural pests worldwide. Bemisia tabaci is a cryptic species complex of more than 40 species among which the invasive MEAM1 and MED species are the most widespread and economically important. Both MEAM1 and MED present intraspecific genetic variability and some haplotypes are reported to be more invasive than others.
View Article and Find Full Text PDFInvestigations into photoreceptor energy metabolism during experimental retinal detachment.
Front Cell Neurosci
November 2022
Ophthalmic Research Laboratories, Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, SA, Australia.
Retinal detachment is a sight-threatening disorder, which occurs when the photoreceptors are separated from their vascular supply. The aim of the present study was to shed light on photoreceptor energy metabolism during experimental detachment in rats. Retinal detachment was induced in the eyes of rats subretinal injection of sodium hyaluronate.
View Article and Find Full Text PDFUnderlying features of epigenetic aging clocks in vivo and in vitro.
Aging Cell
October 2020
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Epigenetic clocks, developed using DNA methylation data, have been widely used to quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks are weakly correlated with each other, suggesting they may capture different biological processes. We utilize multi-omics data from diverse human tissue/cells to identify shared features across eleven existing epigenetic clocks.
View Article and Find Full Text PDFThe Mitochondrial Peptide Humanin Targets but Does Not Denature Amyloid Oligomers in Type II Diabetes.
J Am Chem Soc
September 2019
Department of Pathology , Yale School of Medicine, New Haven , Connecticut 06520 , United States.
Mitochondrially derived peptides (MDPs) such as humanin (HN) have shown a remarkable ability to modulate neurological amyloids and apoptosis-associated proteins in cells and animal models. Recently, we found that humanin-like peptides also inhibit amyloid formation outside of neural environments in islet amyloid polypeptide (IAPP) fibrils and plaques, which are hallmarks of Type II diabetes. However, the biochemical basis for regulating amyloids through endogenous MDPs remains elusive.
View Article and Find Full Text PDFMitochondrial Isolation and Real-Time Monitoring of MOMP.
Methods Mol Biol
May 2019
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Isolated model systems have proven to be the standard in the apoptosis field to deconstruct MOMP into individual steps and to study the behavior of a subset of MOMP regulators. Here we describe the method to isolate, JC-1-label, and purify mouse liver mitochondria and subsequently describe how to utilize the JC-1-labeled mitochondria for real-time MOMP measurements.
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