Aim: This paper reports a study to determine how many older patients are prescribed major and/or minor tranquilizers during their hospital stay, and the perceptions of acute care nursing staff towards the use of such medications with older hospitalized patients.
Background: While considerable research exists on the use of major and minor tranquilizers (chemical restraints) with older people in long-term care, scant research has addressed the use of these drugs with older patients in acute care hospitals. Given the growing numbers of older people with dementia and delirium in hospitals, and the risks these drugs pose to older people, more research on the use of chemical restraints by nurses with older hospital patients is needed.
Methods: Computerized pharmacy records were used to access data on prescriptions of major and minor tranquilizers to older patients during one month on six hospital units (total n = 498), and 140 nursing staff from these units completed the Perceptions of (Chemical) Restraint Use Questionnaire. The data were collected in 2003.
Results: A minority of older patients (8.63%) were prescribed a major or minor tranquilizer during the one-month data collection period. The numbers prescribed minor tranquilizers (6.22%, n = 31) were approximately double that of major tranquilizers (3.21%, n = 16). The majority of prescriptions for minor and major tranquilizers were written as pro re nata or 'as needed' (77% and 55.8%, respectively). Nurses' scores on the Perceptions of (Chemical) Restraint Use Questionnaire indicated perceptions consistent with liberal use of chemical restraints, and several of the highly rated reasons for giving such medications could be considered inappropriate.
Conclusions: While these findings suggest that only a small number of older people were prescribed chemical restraint medications in hospital, the risks these medications pose warrants ongoing prudence. More nursing research and education on the use of these medications with older people in hospital settings is needed.
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http://dx.doi.org/10.1111/j.1365-2648.2006.03893.x | DOI Listing |
Alzheimers Dement
December 2024
University of Kentucky College of Public Health, Lexington, KY, USA.
Background: Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood.
Method: A retrospective cohort study was conducted using the National Alzheimer's Coordinating Center Uniform Data Set (2005-March 2023).
Int J Mol Sci
December 2024
MTA-SE Lendület "Momentum" Diabetes Research Group, 1083 Budapest, Hungary.
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. Current treatments for DKD do not halt renal injury progression, highlighting an urgent need for therapies targeting key disease mechanisms. Our previous studies demonstrated that activating the Sigma-1 receptor (S1R) with fluvoxamine (FLU) protects against acute kidney injury by inhibiting inflammation and ameliorating the effect of hypoxia.
View Article and Find Full Text PDFClin Interv Aging
January 2025
Department of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, People's Republic of China.
Purpose: Low density of electroencephalogram alpha band power was reported to be associated with perioperative cognitive dysfunction. Few studies have conducted to explore the effects of remimazolam on intraoperative frontal alpha band power spectrum density in older adults. Here, we aimed to explore the impact of remimazolam on intraoperative frontal brain wave alpha band activity and postoperative cognitive function in older adults undergoing lower extremity fractures surgeries.
View Article and Find Full Text PDFNeuropsychopharmacol Hung
December 2024
College of Medicine, University of Kentucky, Lexington, KY 40506, USA.
Objective: Benzodiazepines, particularly lorazepam, are good options for acute catatonia treatment. Published catatonia literature on benzodiazepine maintenance treatment and benzodiazepine tolerance is limited.
Methods: This is a chart review covering 30 years of clinical experience in the state of Kentucky, (United States of America), where there was no easy access to electroconvulsive therapy.
J Invest Surg
December 2025
Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Objective: This study aimed to evaluate the effect of co-administration of midazolam and dexmedetomidine on hemodynamics and stress response in elderly patients with non-small cell lung cancer (NSCLC).
Methods: In this prospective, randomized controlled trial, 154 elderly NSCLC patients scheduled for lobectomy in our oncology department from January 2019 to December 2021 were recruited. Patients were randomized 1:1 to receive either dexmedetomidine (control group) or dexmedetomidine plus midazolam (study group) for anesthesia during lobectomy the random number table method, with 77 patients in each group.
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